8EK5
Engineered scFv 10LH bound to PHOX2B/HLA-A24:02
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | MHC class I antigen | polymer | 277 | 31909.3 | 1 | UniProt (F6IR24) Pfam (PF00129) Pfam (PF07654) In PDB | Homo sapiens (human) | |
| 2 | B | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (human) | |
| 3 | C | Paired mesoderm homeobox protein 2B peptide | polymer | 9 | 1140.3 | 1 | UniProt (Q99453) In PDB | Homo sapiens | Neuroblastoma Phox,NBPhox,PHOX2B homeodomain protein,Paired-like homeobox 2B |
| 4 | E | 10LH single chain fragment variable (scFv) | polymer | 464 | 49898.5 | 1 | Homo sapiens (Human) | ||
| 5 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | B, E | NITRATE ION | non-polymer | 62.0 | 2 | Chemie (NO3) | |||
| 7 | water | water | 18.0 | 306 | Chemie (HOH) |
Sequence modifications
A: 2 - 277 (UniProt: F6IR24)
B: 2 - 100 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 94827.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 308.2 | |
| All* | Total formula weight | 95135.7 |
