Author results

3J9M
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STRUCTURE OF THE HUMAN MITOCHONDRIAL RIBOSOME (CLASS 1)
Descriptor:PROTEIN/RNA Complex
Authors:Amunts, A., Brown, A., Toots, J., Scheres, S.H., Ramakrishnan, V.
Deposit date:2015-02-08
Release date:2015-04-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Ribosome. The structure of the human mitochondrial ribosome.
Science, 348, 2015
5GAN
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THE OVERALL STRUCTURE OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP AT 3.7 ANGSTROM
Descriptor:Pre-mRNA-splicing factor 8, U4/U6 small nuclear ribonucleoprotein PRP4, Pre-mRNA-splicing factor 6, Spliceosomal protein DIB1, Pre-mRNA-processing factor 31, U4/U6 small nuclear ribonucleoprotein PRP3, Pre-mRNA-splicing helicase BRR2, Unknown protein, Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Snu66, 13 kDa ribonucleoprotein-associated protein, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, U6 snRNA-associated Sm-like protein LSm4, U6 snRNA-associated Sm-like protein LSm5, U6 snRNA-associated Sm-like protein LSm6, U6 snRNA-associated Sm-like protein LSm7, U6 snRNA-associated Sm-like protein LSm8, Pre-mRNA-splicing factor SNU114/RNA Complex
Authors:Nguyen, T.H.D., Galej, W.P., Bai, X.C., Oubridge, C., Scheres, S.H.W., Newman, A.J., Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2016-05-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5GAO
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HEAD REGION OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP
Descriptor:Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Snu66, Pre-mRNA-splicing helicase BRR2, Pre-mRNA-splicing factor 8/RNA Complex
Authors:Nguyen, T.H.D., Galej, W.P., Bai, X.C., Oubridge, C., Scheres, S.H.W., Newman, A.J., Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2016-03-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
3J6B
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STRUCTURE OF THE YEAST MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT
Descriptor:PROTEIN/RNA Complex
Authors:Amunts, A., Brown, A., Bai, X.C., Llacer, J.L., Hussain, T., Emsley, P., Long, F., Murshudov, G., Scheres, S.H.W., Ramakrishnan, V.
Deposit date:2014-01-22
Release date:2014-04-09
Last modified:2014-12-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the yeast mitochondrial large ribosomal subunit.
Science, 343, 2014
3J79
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CRYO-EM STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTI-PROTOZOAN DRUG EMETINE, LARGE SUBUNIT
Descriptor:PROTEIN/RNA Complex
Authors:Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.
Deposit date:2014-06-02
Release date:2014-07-16
Last modified:2015-06-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3J7A
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CRYO-EM STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTI-PROTOZOAN DRUG EMETINE, SMALL SUBUNIT
Descriptor:PROTEIN/RNA Complex
Authors:Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.
Deposit date:2014-06-03
Release date:2014-07-16
Last modified:2015-06-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3J7O
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STRUCTURE OF THE MAMMALIAN 60S RIBOSOMAL SUBUNIT
Descriptor:PROTEIN/RNA Complex
Authors:Voorhees, R.M., Fernandez, I.S., Scheres, S.H.W., Hegde, R.S.
Deposit date:2014-08-01
Release date:2014-09-03
Last modified:2014-12-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution.
Cell(Cambridge,Mass.), 157, 2014
3J7P
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STRUCTURE OF THE 80S MAMMALIAN RIBOSOME BOUND TO EEF2
Descriptor:PROTEIN/RNA Complex
Authors:Voorhees, R.M., Fernandez, I.S., Scheres, S.H.W., Hegde, R.S.
Deposit date:2014-08-01
Release date:2014-09-03
Last modified:2015-04-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution.
Cell(Cambridge,Mass.), 157, 2014
3J7Q
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STRUCTURE OF THE IDLE MAMMALIAN RIBOSOME-SEC61 COMPLEX
Descriptor:PROTEIN/RNA Complex
Authors:Voorhees, R.M., Fernandez, I.S., Scheres, S.H.W., Hegde, R.S.
Deposit date:2014-08-01
Release date:2014-09-03
Last modified:2014-12-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution.
Cell(Cambridge,Mass.), 157, 2014
3J7R
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STRUCTURE OF THE TRANSLATING MAMMALIAN RIBOSOME-SEC61 COMPLEX
Descriptor:PROTEIN/RNA Complex
Authors:Voorhees, R.M., Fernandez, I.S., Scheres, S.H.W., Hegde, R.S.
Deposit date:2014-08-01
Release date:2014-09-03
Last modified:2015-04-15
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution.
Cell(Cambridge,Mass.), 157, 2014
3J7Y
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STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM HUMAN MITOCHONDRIA
Descriptor:PROTEIN/RNA Complex
Authors:Brown, A., Amunts, A., Bai, X.C., Sugimoto, Y., Edwards, P.C., Murshudov, G., Scheres, S.H.W., Ramakrishnan, V.
Deposit date:2014-08-26
Release date:2014-10-15
Last modified:2014-11-19
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the large ribosomal subunit from human mitochondria.
Science, 346, 2014
3J8H
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STRUCTURE OF THE RABBIT RYANODINE RECEPTOR RYR1 IN COMPLEX WITH FKBP12 AT 3.8 ANGSTROM RESOLUTION
Descriptor:Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A (E.C.5.2.1.8)
Authors:Yan, Z., Bai, X., Yan, C., Wu, J., Scheres, S.H.W., Shi, Y., Yan, N.
Deposit date:2014-10-26
Release date:2014-12-10
Last modified:2015-02-25
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution.
Nature, 517, 2015
3J9K
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STRUCTURE OF DARK APOPTOSOME IN COMPLEX WITH DRONC CARD DOMAIN
Descriptor:Apaf-1 related killer DARK, Caspase Nc (E.C.3.4.22.-)
Authors:Pang, Y., Bai, X., Yan, C., Hao, Q., Chen, Z., Wang, J., Scheres, S.H.W., Shi, Y.
Deposit date:2015-02-04
Release date:2015-02-25
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila.
Genes Dev., 29, 2015
3J9L
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STRUCTURE OF DARK APOPTOSOME FROM DROSOPHILA MELANOGASTER
Descriptor:Apaf-1 related killer DARK
Authors:Pang, Y., Bai, X., Yan, C., Hao, Q., Chen, Z., Wang, J., Scheres, S.H.W., Shi, Y.
Deposit date:2015-02-04
Release date:2015-02-25
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila.
Genes Dev., 29, 2015
4V8Y
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CRYO-EM RECONSTRUCTION OF THE 80S-EIF5B-MET-ITRNAMET EUKARYOTIC TRANSLATION INITIATION COMPLEX
Descriptor:80S Ribosome
Authors:Fernandez, I.S., Bai, X.C., Hussain, T., Kelley, A.C., Lorsch, J.R., Ramakrishnan, V., Scheres, S.H.W.
Deposit date:2013-07-20
Release date:2014-07-09
Last modified:2014-12-10
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Molecular Architecture of a Eukaryotic Translational Initiation Complex.
Science, 342, 2013
4V8Z
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CRYO-EM RECONSTRUCTION OF THE 80S-EIF5B-MET-ITRNAMET EUKARYOTIC TRANSLATION INITIATION COMPLEX
Descriptor:80S Ribosome
Authors:Fernandez, I.S., Bai, X.C., Hussain, T., Kelley, A.C., Lorsch, J.R., Ramakrishnan, V., Scheres, S.H.W.
Deposit date:2013-07-20
Release date:2014-07-09
Last modified:2014-12-10
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Molecular Architecture of a Eukaryotic Translational Initiation Complex.
Science, 342, 2013
5FKU
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CRYO-EM STRUCTURE OF THE E. COLI REPLICATIVE DNA POLYMERASE COMPLEX IN DNA FREE STATE (DNA POLYMERASE III ALPHA, BETA, EPSILON, TAU COMPLEX)
Descriptor:DNA POLYMERASE III SUBUNIT ALPHA (E.C.2.7.7.7), DNA POLYMERASE III SUBUNIT BETA (E.C.2.7.7.7), DNA POLYMERASE III SUBUNIT EPSILON (E.C.2.7.7.7), DNA POLYMERASE III SUBUNIT TAU (E.C.2.7.7.7)
Authors:Fernandez-Leiro, R., Conrad, J., Scheres, S.H.W., Lamers, M.H.
Deposit date:2015-10-20
Release date:2015-11-25
Last modified:2017-04-19
Method:ELECTRON MICROSCOPY (8.34 Å)
Cite:cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and tau.
Elife, 4, 2015
5FKV
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CRYO-EM STRUCTURE OF THE E. COLI REPLICATIVE DNA POLYMERASE COMPLEX BOUND TO DNA (DNA POLYMERASE III ALPHA, BETA, EPSILON, TAU COMPLEX)
Descriptor:DNA POLYMERASE III SUBUNIT ALPHA (E.C.2.7.7.7), DNA POLYMERASE III BETA (E.C.2.7.7.7), DNA POLYMERASE III EPSILON (E.C.2.7.7.7), DNA POLYMERASE III TAU (E.C.2.7.7.7)
Authors:Fernandez-Leiro, R., Conrad, J., Scheres, S.H.W., Lamers, M.H.
Deposit date:2015-10-20
Release date:2015-11-25
Last modified:2017-04-19
Method:ELECTRON MICROSCOPY (8 Å)
Cite:cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and tau.
Elife, 4, 2015
5FKW
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CRYO-EM STRUCTURE OF THE E. COLI REPLICATIVE DNA POLYMERASE COMPLEX BOUND TO DNA (DNA POLYMERASE III ALPHA, BETA, EPSILON)
Descriptor:DNA POLYMERASE III ALPHA (E.C.2.7.7.7), DNA POLYMERASE III BETA (E.C.2.7.7.7), DNA POLYMERASE III EPSILON (E.C.2.7.7.7)
Authors:Fernandez-Leiro, R., Conrad, J., Scheres, S.H.W., Lamers, M.H.
Deposit date:2015-10-20
Release date:2015-11-25
Last modified:2017-04-19
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and tau.
Elife, 4, 2015
5FN2
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CRYO-EM STRUCTURE OF GAMMA SECRETASE IN COMPLEX WITH A DRUG DAPT
Descriptor:NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2
Authors:Bai, X.C., Rajendra, E., Yang, G.H., Shi, Y.G., Scheres, S.H.W.
Deposit date:2015-11-10
Release date:2015-12-16
Last modified:2016-12-21
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
5FN3
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CRYO-EM STRUCTURE OF GAMMA SECRETASE IN CLASS 1 OF THE APO- STATE ENSEMBLE
Descriptor:NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2, POLY ALA CHAIN
Authors:Bai, X.C., Rajendra, E., Yang, G.H., Shi, Y.G., Scheres, S.H.W.
Deposit date:2015-11-10
Release date:2015-12-16
Last modified:2016-12-21
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
5FN4
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CRYO-EM STRUCTURE OF GAMMA SECRETASE IN CLASS 2 OF THE APO- STATE ENSEMBLE
Descriptor:NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2, POLY ALA CHAIN
Authors:Bai, X.C., Rajendra, E., Yang, G.H., Shi, Y.G., Scheres, S.H.W.
Deposit date:2015-11-10
Release date:2015-12-16
Last modified:2016-12-21
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
5FN5
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CRYO-EM STRUCTURE OF GAMMA SECRETASE IN CLASS 3 OF THE APO- STATE ENSEMBLE
Descriptor:NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2
Authors:Bai, X.C., Rajendra, E., Yang, G.H., Shi, Y.G., Scheres, S.H.W.
Deposit date:2015-11-10
Release date:2015-12-16
Last modified:2016-12-21
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
5GAP
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BODY REGION OF THE U4/U6.U5 TRI-SNRNP
Descriptor:unknown protein, Pre-mRNA-splicing factor 8, U4/U6 small nuclear ribonucleoprotein PRP4, Pre-mRNA-splicing factor 6, Spliceosomal protein DIB1, Pre-mRNA-processing factor 31, U4/U6 small nuclear ribonucleoprotein PRP3, 13 kDa ribonucleoprotein-associated protein, Pre-mRNA-splicing helicase BRR2/RNA Complex
Authors:Nguyen, T.H.D., Galej, W.P., Oubridge, C., Bai, X.C., Newman, A., Scheres, S., Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2016-03-09
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5M1S
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CRYO-EM STRUCTURE OF THE E. COLI REPLICATIVE DNA POLYMERASE-CLAMP-EXONUCLASE-THETA COMPLEX BOUND TO DNA IN THE EDITING MODE
Descriptor:DNA polymerase III subunit alpha, DNA polymerase III subunit beta, DNA polymerase III subunit epsilon, DNA polymerase III subunit theta/DNA Complex
Authors:Fernandez-Leiro, R., Conrad, J., Scheres, S.H.W., Lamers, M.H.
Deposit date:2016-10-10
Release date:2017-01-18
Last modified:2017-02-15
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Self-correcting mismatches during high-fidelity DNA replication.
Nat. Struct. Mol. Biol., 24, 2017
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