Author results

1A1R
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HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX
分子名称:NS3 PROTEIN, NS4A PROTEIN, ZINC ION
著者Kim, J.L., Morgenstern, K.A., Lin, C., Fox, T., Dwyer, M.D., Landro, J.A., Chambers, S.P., Markland, W., Lepre, C.A., O'Malley, E.T., Harbeson, S.L., Rice, C.M., Murcko, M.A., Caron, P.R., Thomson, J.A.
登録日1997-12-15
公開日1998-06-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide.
Cell(Cambridge,Mass.), 87, 1996
1ZH1
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STRUCTURE OF THE ZINC-BINDING DOMAIN OF HCV NS5A
分子名称:non-structural polyprotein, ZINC ION
著者Tellinghuisen, T.L., Marcotrigiano, J., Rice, C.M.
登録日2005-04-22
公開日2005-05-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase.
Nature, 435, 2005
2HD0
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STRUCTURE OF THE CATALYTIC DOMAIN OF HEPATITIS C VIRUS NS2
分子名称:Protease NS2-3 (p23), B-OCTYLGLUCOSIDE, DECYL-BETA-D-MALTOPYRANOSIDE
著者Lorenz, I.C., Rice, C.M., Marcotrigiano, J.
登録日2006-06-19
公開日2006-08-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Structure of the catalytic domain of the hepatitis C virus NS2-3 protease.
Nature, 442, 2006
3KQH
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THREE CONFORMATIONAL SNAPSHOTS OF THE HEPATITIS C VIRUS NS3 HELICASE REVEAL A RATCHET TRANSLOCATION MECHANISM
分子名称:Serine protease/NTPase/helicase NS3, 5'-D(*AP*AP*AP*AP*AP*A)-3'
著者Gu, M., Rice, C.M.
登録日2009-11-17
公開日2010-01-26
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KQK
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THREE CONFORMATIONAL SNAPSHOTS OF THE HEPATITIS C VIRUS NS3 HELICASE REVEAL A RATCHET TRANSLOCATION MECHANISM
分子名称:Serine protease/NTPase/helicase NS3, 5'-D(*TP*TP*TP*TP*TP*T)-3'
著者Gu, M., Rice, C.M.
登録日2009-11-17
公開日2010-01-26
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KQL
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THREE CONFORMATIONAL SNAPSHOTS OF THE HEPATITIS C VIRUS NS3 HELICASE REVEAL A RATCHET TRANSLOCATION MECHANISM
分子名称:Serine protease/NTPase/helicase NS3, 5'-D(*TP*TP*TP*TP*TP*T)-3', TETRAFLUOROALUMINATE ION, ...
著者Gu, M., Rice, C.M.
登録日2009-11-17
公開日2010-01-26
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KQN
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THREE CONFORMATIONAL SNAPSHOTS OF THE HEPATITIS C VIRUS NS3 HELICASE REVEAL A RATCHET TRANSLOCATION MECHANISM
分子名称:Serine protease/NTPase/helicase NS3, 5'-D(*TP*TP*TP*TP*TP*T)-3', BERYLLIUM TRIFLUORIDE ION, ...
著者Gu, M., Rice, C.M.
登録日2009-11-17
公開日2010-01-26
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KQU
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THREE CONFORMATIONAL SNAPSHOTS OF THE HEPATITIS C VIRUS NS3 HELICASE REVEAL A RATCHET TRANSLOCATION MECHANISM
分子名称:Serine protease/NTPase/helicase NS3, 5'-D(*T*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3', BERYLLIUM TRIFLUORIDE ION, ...
著者Gu, M., Rice, C.M.
登録日2009-11-17
公開日2010-01-26
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Inaugural Article: Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Proc.Natl.Acad.Sci.USA, 107, 2010
4J1V
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FUNCTIONAL AND STRUCTURAL STUDIES OF MOBKL1B, A SALVADOR/WARTS/HIPPO TUMOR SUPPRESSOR PATHWAY, IN HCV REPLICATION
分子名称:MOB kinase activator 1A, NS5A domain II peptide, ZINC ION
著者Chung, H.-Y., Gu, M., Rice, C.M.
登録日2013-02-02
公開日2014-08-06
最終更新日2014-09-24
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Seed Sequence-Matched Controls Reveal Limitations of Small Interfering RNA Knockdown in Functional and Structural Studies of Hepatitis C Virus NS5A-MOBKL1B Interaction.
J.Virol., 88, 2014
5E4F
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THE SPRING ALPHA-HELIX COORDINATES MULTIPLE MODES OF HCV NS3 HELICASE ACTION
分子名称:Serine protease NS3, TETRAFLUOROALUMINATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
著者Gu, M., Rice, C.M.
登録日2015-10-05
公開日2016-05-18
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Spring alpha-Helix Coordinates Multiple Modes of HCV (Hepatitis C Virus) NS3 Helicase Action.
J.Biol.Chem., 291, 2016
1BT7
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THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES
分子名称:NS3 SERINE PROTEASE, ZINC ION
著者Barbato, G., Cicero, D.O., Nardi, M.C., Steinkuhler, C., Cortese, R., De Francesco, R., Bazzo, R.
登録日1998-09-01
公開日1999-06-22
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism.
J.Mol.Biol., 289, 1999
3P5O
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH IBET INHIBITOR
分子名称:Bromodomain-containing protein 4, 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide, 1,2-ETHANEDIOL
著者Chung, C.
登録日2010-10-09
公開日2010-11-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Suppression of inflammation by a synthetic histone mimic
Nature, 468, 2010
4PIF
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CRYSTAL STRUCTURE OF RECOMBINANT WT BANANA LECTIN
分子名称:Ripening-associated protein, GLYCEROL
著者Meagher, J.L., Stuckey, J.A.
登録日2014-05-08
公開日2015-11-04
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity.
Cell, 163, 2015
4PIK
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CRYSTAL STRUCTURE OF BANANA LECTIN BOUND TO DIMANNOSE
分子名称:Ripening-associated protein, ALPHA-D-MANNOSE, GLYCEROL
著者Meagher, J.L., Stuckey, J.A.
登録日2014-05-08
公開日2015-11-04
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity.
Cell, 163, 2015
4PIT
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CRYSTAL STRUCTURE OF BANANA LECTIN H84T BOUND TO DIMANNOSE
分子名称:Ripening-associated protein, ALPHA-D-MANNOSE, GLYCEROL
著者Meagher, J.L., Stuckey, J.A.
登録日2014-05-09
公開日2015-11-04
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity.
Cell, 163, 2015
4PIU
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CRYSTAL STRUCTURE OF BANANA LECTIN H84T MUTANT
分子名称:Ripening-associated protein, SODIUM ION, GLYCEROL
著者Meagher, J.L., Stuckey, J.A.
登録日2014-05-09
公開日2015-11-04
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity.
Cell, 163, 2015
5T5W
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STRUCTURE OF AN AFFINITY MATURED LAMBDA-IFN/IFN-LAMBDAR1/IL-10RBETA RECEPTOR COMPLEX
分子名称:Interleukin-10 receptor subunit beta, Interferon lambda receptor 1, Interferon lambda-3, ...
著者Mendoza, J.L., Jude, K.M., Garcia, K.C.
登録日2016-08-31
公開日2017-03-29
最終更新日2018-08-15
実験手法X-RAY DIFFRACTION (2.847 Å)
主引用文献The IFN-lambda-IFN-lambda R1-IL-10R beta Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.
Immunity, 46, 2017
5VIC
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CRYSTAL STRUCTURE OF ANTI-ZIKA ANTIBODY Z004 BOUND TO DENV-1 ENVELOPE PROTEIN DIII
分子名称:Fab heavy chain, Fab light chain, Dengue 1 Envelope DIII domain
著者Keeffe, J.R., West Jr., A.P., Gristick, H.B., Bjorkman, P.J.
登録日2017-04-14
公開日2017-05-03
最終更新日2017-05-17
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.
Cell, 169, 2017
5VIG
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CRYSTAL STRUCTURE OF ANTI-ZIKA ANTIBODY Z006 BOUND TO ZIKA VIRUS ENVELOPE PROTEIN DIII
分子名称:Fab heavy chain, Fab light chain, Zika virus envelope protein DIII, ...
著者Keeffe, J.R., West Jr., A.P., Gristick, H.B., Bjorkman, P.J.
登録日2017-04-16
公開日2017-05-03
最終更新日2017-05-17
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.
Cell, 169, 2017
6DFI
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CRYSTAL STRUCTURE OF ANTI-ZIKA ANTIBODY Z021 BOUND TO ZIKA VIRUS ENVELOPE PROTEIN DIII
分子名称:anti-Zika antibody Z021, Heavy Chain, Light Chain, ...
著者Keeffe, J.R., Bjorkman, P.J.
登録日2018-05-14
公開日2018-10-24
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates.
Cell Rep, 25, 2018
6DFJ
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CRYSTAL STRUCTURE OF ANTI-ZIKA ANTIBODY Z021 BOUND TO DENV-1 ENVELOPE PROTEIN DIII
分子名称:anti-Zika antibody Z021, Heavy Chain, Light Chain, ...
著者Keeffe, J.R., Bjorkman, P.J.
登録日2018-05-14
公開日2018-10-24
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates.
Cell Rep, 25, 2018
2A4G
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HEPATITIS C PROTEASE NS3-4A SERINE PROTEASE WITH KETOAMIDE INHIBITOR SCH225724 BOUND
分子名称:NS3 protease/helicase, NS4a peptide, ZINC ION, ...
著者Arasappan, A., Njoroge, F.G., Chan, T.Y., Bennett, F., Bogen, S.L., Chen, K., Gu, H., Hong, L., Jao, E., Liu, Y.T., Lovey, R.G., Parekh, T., Pike, R.E., Pinto, P., Santhanam, B., Venkatraman, S., Vaccaro, H., Wang, H., Yang, X., Zhu, Z., Mckittrick, B., Saksena, A.K., Girijavallabhan, V., Pichardo, J., Butkiewicz, N., Ingram, R., Malcolm, B., Prongay, A.J., Yao, N., Marten, B., Madison, V., Kemp, S., Levy, O., Lim-Wilby, M., Tamura, S., Ganguly, A.K.
登録日2005-06-28
公開日2006-07-04
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Hepatitis C virus NS3-4a serine protease inhibitors. SAR of P2' moiety with improved potency.
Bioorg.Med.Chem.Lett., 15, 2005
2A4Q
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HCV NS3 PROTEASE WITH NS4A PEPTIDE AND A COVALENTLY BOUND MACROCYCLIC KETOAMIDE COMPOUND.
分子名称:NS3 protease/helicase', NS4a peptide, ZINC ION, ...
著者Chen, K.X., Njoroge, F.G., Prongay, A., Pichardo, J., Madison, V., Girijavallabhan, V.
登録日2005-06-29
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Synthesis and Biological Activity of Macrocyclic Inhibitors of Hepatitis C Virus (HCV) NS3 Protease
Bioorg.Med.Chem.Lett., 15, 2005
2A4R
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HCV NS3 PROTEASE DOMAIN WITH A KETOAMIDE INHIBITOR COVALENTLY BOUND.
分子名称:NS3 protease/helicase, Ns4a peptide, ZINC ION, ...
著者Bogen, S., Saksena, A.K., Arasappan, A., Gu, H., Njoroge, F.G., Girijavallabhan, V., Pichardo, J., Butkiewicz, N., Prongay, A., Madison, V.
登録日2005-06-29
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Hepatitis C Virus NS3-4A serine protease inhibitors: Use of a P2-P1 cyclopropyl alanine combination for improved potency.
Bioorg.Med.Chem.Lett., 15, 2005
2F9U
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HCV NS3 PROTEASE DOMAIN WITH NS4A PEPTIDE AND A KETOAMIDE INHIBITOR WITH A P2 NORBORANE
分子名称:NS3 protease/helicase', polyprotein, ZINC ION, ...
著者Venkatraman, S., Njoroge, F.G., Wu, W., Girijavallabhan, V., Prongay, A.J., Butkiewicz, N., Pichardo, J.
登録日2005-12-06
公開日2006-06-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Novel Inhibitors of Hepatitis C NS3-NS4A Serine Protease Derived from 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid.
Bioorg.Med.Chem.Lett., 16, 2006
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