3KQU
Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism
Summary for 3KQU
Entry DOI | 10.2210/pdb3kqu/pdb |
Related | 3KQH 3KQK 3KQL 3KQN |
Descriptor | Serine protease/NTPase/helicase NS3, 5'-D(*T*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3', BERYLLIUM TRIFLUORIDE ION, ... (6 entities in total) |
Functional Keywords | helicase-substrate ground-state complex, hcv, ns3 protein, helicase, dna-binding, hydrolase-dna complex, hydrolase/dna |
Biological source | Hepatitis C virus (HCV) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : Q9WMX2 |
Total number of polymer chains | 8 |
Total formula weight | 295210.64 |
Authors | Gu, M.,Rice, C.M. (deposition date: 2009-11-17, release date: 2010-01-26, Last modification date: 2024-02-21) |
Primary citation | Gu, M.,Rice, C.M. Inaugural Article: Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc.Natl.Acad.Sci.USA, 107:521-528, 2010 Cited by PubMed: 20080715DOI: 10.1073/pnas.0913380107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report