3KQU
Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Serine protease/NTPase/helicase NS3 | polymer | 437 | 46742.1 | 6 | UniProt (Q9WMX2) Pfam (PF07652) Pfam (PF22027) | Hepatitis C virus (HCV) | Core protein p21, Capsid protein C, p21, Core protein p19, Envelope glycoprotein E1, gp32, gp35, Envelope glycoprotein E2, NS1, gp68, gp70, p7, Protease NS2-3, p23, Serine protease/NTPase/helicase NS3, Hepacivirin, NS3P, p70, Non-structural protein 4A, NS4A, p8, Non-structural protein 4B, NS4B, p27, Non-structural protein 5A, NS5A, p56, RNA-directed RNA polymerase, NS5B, p68 |
| 2 | G, H (M, N) | 5'-D(*T*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3' | polymer | 19 | 5734.7 | 2 | |||
| 3 | I, L, O, R, U... (A, B, C, D, E...) | BERYLLIUM TRIFLUORIDE ION | non-polymer | 66.0 | 6 | Chemie (BEF) | |||
| 4 | J, M, P, S, V... (A, B, C, D, E...) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 6 | Chemie (ADP) | |||
| 5 | K, N, Q, T, W... (A, B, C, D, E...) | MANGANESE (II) ION | non-polymer | 54.9 | 6 | Chemie (MN) | |||
| 6 | AA, BA, CA, DA, EA... (A, B, C, D, E...) | water | water | 18.0 | 427 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 189 - 624 (UniProt: Q9WMX2)
| PDB | External Database | Details |
|---|---|---|
| Ala 625 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 291921.8 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3288.9 | |
| All* | Total formula weight | 295210.6 |
