3KQU

Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
B	0004386	molecular_function	helicase activity
B	0005524	molecular_function	ATP binding
C	0004386	molecular_function	helicase activity
C	0005524	molecular_function	ATP binding
D	0004386	molecular_function	helicase activity
D	0005524	molecular_function	ATP binding
E	0004386	molecular_function	helicase activity
E	0005524	molecular_function	ATP binding
F	0004386	molecular_function	helicase activity
F	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BEF A 1

Chain	Residue
A	ADP2
A	ARG467
A	HOH626
A	HOH627
A	HOH628
A	MN3
A	HOH4
A	THR206
A	GLY207
A	LYS210
A	GLU291
A	ALA323
A	ARG464

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP A 2

Chain	Residue
A	BEF1
A	MN3
A	HOH4
A	HOH5
A	GLY207
A	SER208
A	GLY209
A	LYS210
A	SER211
A	THR212
A	GLY237
A	TYR241
A	THR419
A	ARG467
A	GLY468
A	HOH628

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 3

Chain	Residue
A	BEF1
A	ADP2
A	HOH4
A	SER211
A	ASP290
A	GLU291
A	HOH628

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE BEF B 1

Chain	Residue
B	ADP2
B	MN3
B	HOH6
B	HOH7
B	HOH8
B	HOH9
B	THR206
B	LYS210
B	GLU291
B	ALA323
B	ARG464
B	ARG467

---

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP B 2

Chain	Residue
B	BEF1
B	MN3
B	HOH8
B	HOH9
B	HOH10
B	GLY207
B	SER208
B	GLY209
B	LYS210
B	SER211
B	THR212
B	GLY237
B	TYR241
B	THR419
B	ARG467
B	GLY468
B	HOH633
B	HOH662

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN B 3

Chain	Residue
B	BEF1
B	ADP2
B	HOH8
B	HOH9
B	SER211
B	ASP290
B	GLU291

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BEF C 1

Chain	Residue
C	ADP2
C	MN3
C	HOH11
C	HOH12
C	HOH13
C	HOH14
C	THR206
C	GLY207
C	LYS210
C	GLU291
C	ALA323
C	ARG464
C	ARG467

---

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP C 2

Chain	Residue
C	THR419
C	ARG467
C	GLY468
C	BEF1
C	MN3
C	HOH13
C	HOH14
C	HOH15
C	GLY207
C	SER208
C	GLY209
C	LYS210
C	SER211
C	THR212
C	GLY237
C	TYR241

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN C 3

Chain	Residue
C	BEF1
C	ADP2
C	HOH13
C	HOH14
C	SER211
C	ASP290
C	GLU291

---

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BEF D 1

Chain	Residue
D	ADP2
D	MN3
D	HOH16
D	HOH17
D	HOH18
D	HOH19
D	THR206
D	GLY207
D	LYS210
D	GLU291
D	ALA323
D	ARG464
D	ARG467

---

site_id	BC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP D 2

Chain	Residue
D	BEF1
D	MN3
D	HOH18
D	HOH19
D	HOH20
D	GLY207
D	SER208
D	GLY209
D	LYS210
D	SER211
D	THR212
D	GLY237
D	TYR241
D	THR419
D	ARG467
D	GLY468

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN D 3

Chain	Residue
D	BEF1
D	ADP2
D	HOH18
D	HOH19
D	SER211
D	ASP290
D	GLU291

---

site_id	BC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BEF E 1

Chain	Residue
E	ADP2
E	MN3
E	HOH21
E	HOH22
E	HOH23
E	HOH24
E	THR206
E	GLY207
E	LYS210
E	GLU291
E	ALA323
E	ARG464
E	ARG467

---

site_id	BC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP E 2

Chain	Residue
E	BEF1
E	MN3
E	HOH23
E	HOH24
E	HOH25
E	GLY207
E	SER208
E	GLY209
E	LYS210
E	SER211
E	THR212
E	GLY237
E	TYR241
E	THR419
E	ARG467
E	GLY468

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN E 3

Chain	Residue
E	BEF1
E	ADP2
E	HOH23
E	HOH24
E	SER211
E	ASP290
E	GLU291

---

site_id	BC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BEF F 1

Chain	Residue
F	ADP2
F	MN3
F	HOH26
F	HOH27
F	HOH28
F	HOH29
F	THR206
F	GLY207
F	LYS210
F	GLU291
F	ALA323
F	ARG464
F	ARG467

---

site_id	BC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP F 2

Chain	Residue
F	BEF1
F	MN3
F	HOH28
F	HOH29
F	HOH30
F	GLY207
F	SER208
F	GLY209
F	LYS210
F	SER211
F	THR212
F	GLY237
F	TYR241
F	THR419
F	ARG467
F	GLY468
F	HOH642

---

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN F 3

Chain	Residue
F	BEF1
F	ADP2
F	HOH28
F	HOH29
F	SER211
F	ASP290
F	GLU291

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	912
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	66
Details	Region: {"description":"RNA-binding","evidences":[{"source":"UniProtKB","id":"P26663","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Motif: {"description":"DECH box","evidences":[{"source":"UniProtKB","id":"Q99IB8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20080715","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---