3KQN

Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism

Summary for 3KQN

• Entry DOI: 10.2210/pdb3kqn/pdb
• Related: 3KQH 3KQK 3KQL 3KQU
• Descriptor: Serine protease/NTPase/helicase NS3, 5'-D(*TP*TP*TP*TP*TP*T)-3', BERYLLIUM TRIFLUORIDE ION, ... (6 entities in total)
• Functional Keywords: helicase-substrate transition-state complex, hcv, ns3 protein, helicase, dna-binding, hydrolase-dna complex, hydrolase/dna
• Biological source: Hepatitis C virus (HCV)
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : Q9WMX2
• Total number of polymer chains: 2
• Total formula weight: 49070.40

Authors

Gu, M.,Rice, C.M. (deposition date: 2009-11-17, release date: 2010-01-26, Last modification date: 2024-02-21)

• Primary citation: Gu, M.,Rice, C.M.; Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.; Proc.Natl.Acad.Sci.USA, 107:521-528, 2010; PubMed: 20080715; DOI: 10.1073/pnas.0913380107

Experimental method

X-RAY DIFFRACTION (2.05 Å)