3KQN
Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Serine protease/NTPase/helicase NS3 | polymer | 437 | 46742.1 | 1 | UniProt (Q9WMX2) Pfam (PF07652) Pfam (PF22027) In PDB | Hepatitis C virus (HCV) | Core protein p21, Capsid protein C, p21, Core protein p19, Envelope glycoprotein E1, gp32, gp35, Envelope glycoprotein E2, NS1, gp68, gp70, p7, Protease NS2-3, p23, Serine protease/NTPase/helicase NS3, Hepacivirin, NS3P, p70, Non-structural protein 4A, NS4A, p8, Non-structural protein 4B, NS4B, p27, Non-structural protein 5A, NS5A, p56, RNA-directed RNA polymerase, NS5B, p68 |
2 | E | 5'-D(*TP*TP*TP*TP*TP*T)-3' | polymer | 6 | 1780.2 | 1 | |||
3 | A | BERYLLIUM TRIFLUORIDE ION | non-polymer | 66.0 | 1 | Chemie (BEF) | |||
4 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
5 | A | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
6 | water | water | 18.0 | 223 | Chemie (HOH) |
Sequence modifications
A: 189 - 624 (UniProt: Q9WMX2)
PDB | External Database | Details |
---|---|---|
Ala 625 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 48522.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 548.1 | |
All* | Total formula weight | 49070.4 |