1BT7

THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES

Summary for 1BT7

DescriptorNS3 SERINE PROTEASE, ZINC ION (2 entities in total)
Functional Keywordshydrolase, viral non-structural protein, serine protease
Biological sourceHepatitis C virus
Cellular locationCore protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential) P26663
Total number of polymer chains1
Total molecular weight19699.94
Authors
Barbato, G.,Cicero, D.O.,Nardi, M.C.,Steinkuhler, C.,Cortese, R.,De Francesco, R.,Bazzo, R. (deposition date: 1998-09-01, release date: 1999-06-22, Last modification date: 2011-07-13)
Primary citation
Barbato, G.,Cicero, D.O.,Nardi, M.C.,Steinkuhler, C.,Cortese, R.,De Francesco, R.,Bazzo, R.
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism.
J.Mol.Biol., 289:371-384, 1999
PubMed: 10366511 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.1999.2745
MImport into Mendeley
Experimental method
SOLUTION NMR
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers298.0%21.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload