1BT7
THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES
Summary for 1BT7
| Entry DOI | 10.2210/pdb1bt7/pdb |
| Descriptor | NS3 SERINE PROTEASE, ZINC ION (2 entities in total) |
| Functional Keywords | hydrolase, viral non-structural protein, serine protease |
| Biological source | Hepatitis C virus |
| Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663 |
| Total number of polymer chains | 1 |
| Total formula weight | 19699.94 |
| Authors | Barbato, G.,Cicero, D.O.,Nardi, M.C.,Steinkuhler, C.,Cortese, R.,De Francesco, R.,Bazzo, R. (deposition date: 1998-09-01, release date: 1999-06-22, Last modification date: 2022-02-16) |
| Primary citation | Barbato, G.,Cicero, D.O.,Nardi, M.C.,Steinkuhler, C.,Cortese, R.,De Francesco, R.,Bazzo, R. The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism. J.Mol.Biol., 289:371-384, 1999 Cited by PubMed: 10366511DOI: 10.1006/jmbi.1999.2745 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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