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1EJ9
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BU of 1ej9 by Molmil
CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX
Descriptor: DNA (5'-D(*C*AP*AP*AP*AP*AP*GP*AP*CP*TP*CP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'), DNA (5'-D(*C*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*GP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), DNA TOPOISOMERASE I
Authors:Redinbo, M.R, Champoux, J.J, Hol, W.G.
Deposit date:2000-03-01
Release date:2000-08-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA.
Biochemistry, 39, 2000
2PLT
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BU of 2plt by Molmil
STRUCTURE DETERMINATION OF PLASTOCYANIN FROM A CRYSTAL SPECIMEN WITH HEMIHEDRAL TWINNING FRACTION OF ONE-HALF
Descriptor: CALCIUM ION, COPPER (II) ION, PLASTOCYANIN
Authors:Redinbo, M.R, Merchant, S, Yeates, T.O.
Deposit date:1993-05-06
Release date:1993-10-31
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The 1.5-A crystal structure of plastocyanin from the green alga Chlamydomonas reinhardtii.
Biochemistry, 32, 1993
1A35
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BU of 1a35 by Molmil
HUMAN TOPOISOMERASE I/DNA COMPLEX
Descriptor: DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*(BRU)P*(BRU)P*TP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*+UP*+UP*+UP*+UP*CP*+UP*AP*AP*GP*TP*CP*TP*TP*TP*+ UP*T)-3'), PROTEIN (DNA TOPOISOMERASE I)
Authors:Redinbo, M.R, Stewart, L, Kuhn, P, Champoux, J.J, Hol, W.G.
Deposit date:1998-01-29
Release date:1998-08-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Science, 279, 1998
1A31
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BU of 1a31 by Molmil
HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor: DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*5IUP*5IU*TP*GP*AP*AP*AP*AP*AP*5IUP*5IUP*5IUP*5IUP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*5IUP*5IUP*5IUP*5IUP*CP*AP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), PROTEIN (TOPOISOMERASE I)
Authors:Redinbo, M.R, Stewart, L, Kuhn, P, Champoux, J.J, Hol, W.G.J.
Deposit date:1998-01-27
Release date:1998-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Science, 279, 1998
3L57
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BU of 3l57 by Molmil
Crystal Structure of the Plasmid pCU1 TraI Relaxase Domain
Descriptor: 1,2-ETHANEDIOL, CITRIC ACID, MANGANESE (III) ION, ...
Authors:Redinbo, M.R, Nash, R.P.
Deposit date:2009-12-21
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.293 Å)
Cite:The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1.
Nucleic Acids Res., 38, 2010
3HX6
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BU of 3hx6 by Molmil
Crystal structure of Pseudomonas aeruginosa PilY1 C-terminal domain
Descriptor: CALCIUM ION, Type 4 fimbrial biogenesis protein PilY1
Authors:Redinbo, M.R, Orans, J.
Deposit date:2009-06-19
Release date:2010-01-26
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility.
Proc.Natl.Acad.Sci.USA, 107, 2010
3L6T
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BU of 3l6t by Molmil
Crystal Structure of an N-terminal Mutant of the Plasmid pCU1 TraI Relaxase Domain
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, CITRIC ACID, ...
Authors:Redinbo, M.R, Nash, R.P.
Deposit date:2009-12-24
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1.
Nucleic Acids Res., 38, 2010
3LPF
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BU of 3lpf by Molmil
Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea
Descriptor: 1-[(6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea, Beta-glucuronidase
Authors:Wallace, B.D, Redinbo, M.R.
Deposit date:2010-02-05
Release date:2010-11-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.
Science, 330, 2010
3LPG
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BU of 3lpg by Molmil
Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 3-(2-fluorophenyl)-1-(2-hydroxyethyl)-1-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea
Descriptor: 3-(2-fluorophenyl)-1-(2-hydroxyethyl)-1-[(6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]urea, Beta-glucuronidase
Authors:Wallace, B.D, Redinbo, M.R.
Deposit date:2010-02-05
Release date:2010-11-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.425 Å)
Cite:Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.
Science, 330, 2010
5I7J
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BU of 5i7j by Molmil
Crystal Structure of Human SPLUNC1 Disulfide Mutant M3 (I76C, V214C)
Descriptor: BPI fold-containing family A member 1
Authors:Walton, W.G, Redinbo, M.R.
Deposit date:2016-02-17
Release date:2016-05-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.544 Å)
Cite:Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1.
Biochemistry, 55, 2016
5I7K
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BU of 5i7k by Molmil
Crystal Structure of Human SPLUNC1 Dolphin Mutant D1 (G58A, S61A, G62E, G63D, G66D, I67T)
Descriptor: BPI fold-containing family A member 1
Authors:Walton, W.G, Redinbo, M.R.
Deposit date:2016-02-17
Release date:2016-05-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.552 Å)
Cite:Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1.
Biochemistry, 55, 2016
5I7L
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BU of 5i7l by Molmil
Crystal Structure of SPLUNC1 Disulfide Mutant M2 (A48C, V253C)
Descriptor: BPI fold-containing family A member 1
Authors:Walton, W.G, Redinbo, M.R.
Deposit date:2016-02-17
Release date:2016-05-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.598 Å)
Cite:Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1.
Biochemistry, 55, 2016
5FF5
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BU of 5ff5 by Molmil
Crystal Structure of SeMet PaaA
Descriptor: GLYCEROL, NICKEL (II) ION, PaaA, ...
Authors:Biernat, K.B, Redinbo, M.R.
Deposit date:2015-12-17
Release date:2016-04-27
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (2.933 Å)
Cite:Post-translational Claisen Condensation and Decarboxylation en Route to the Bicyclic Core of Pantocin A.
J.Am.Chem.Soc., 138, 2016
9B9N
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BU of 9b9n by Molmil
Crystal structure of FlcD from Pseudomonas aeruginosa bound to iron (II) and substrate
Descriptor: (2R)-2-{[(2Z)-2-(hydroxyimino)ethyl]sulfanyl}butanedioic acid, FE (III) ION, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C
Authors:Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R.
Deposit date:2024-04-02
Release date:2024-07-31
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme.
Acs Cent.Sci., 10, 2024
9B9O
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BU of 9b9o by Molmil
Crystal structure of FlcD from Pseudomonas aeruginosa bond to iron(II) and substrate
Descriptor: (2R)-2-{[(2Z)-2-(hydroxyimino)ethyl]sulfanyl}butanedioic acid, FE (II) ION, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C
Authors:Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R.
Deposit date:2024-04-02
Release date:2024-07-31
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme.
Acs Cent.Sci., 10, 2024
9B9M
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BU of 9b9m by Molmil
Crystal structure of iron-bound FlcD from Pseudomonas aeruginosa
Descriptor: FE (II) ION, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C
Authors:Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R.
Deposit date:2024-04-02
Release date:2024-07-31
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme.
Acs Cent.Sci., 10, 2024
8UGT
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BU of 8ugt by Molmil
E. eligens beta-glucuronidase bound to UNC10206581-G
Descriptor: 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(methylamino)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinoline, Beta-glucuronidase, GLYCEROL, ...
Authors:Simpson, J.B, Redinbo, M.R.
Deposit date:2023-10-06
Release date:2024-07-24
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Advanced piperazine-containing inhibitors target microbial beta-glucuronidases linked to gut toxicity.
Rsc Chem Biol, 5, 2024
8W1Q
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BU of 8w1q by Molmil
Aerobic crystal structure of iron-bound FlcD from Pseudomonas aeruginosa
Descriptor: FE (II) ION, GLYCEROL, MAGNESIUM ION, ...
Authors:Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R.
Deposit date:2024-02-17
Release date:2024-07-31
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme.
Acs Cent.Sci., 10, 2024
5CZK
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BU of 5czk by Molmil
Structure of E. coli beta-glucuronidase bound with a novel, potent inhibitor 1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(4-hydroxyphenyl)thiourea
Descriptor: 1-[(6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-hydroxyethyl)-3-(4-hydroxyphenyl)thiourea, Beta-glucuronidase
Authors:Roberts, A.R, Wallace, B.R, Redinbo, M.R.
Deposit date:2015-07-31
Release date:2015-10-14
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure and Inhibition of Microbiome beta-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.
Chem.Biol., 22, 2015
6MVH
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BU of 6mvh by Molmil
Crystal structure of FMN-binding beta-glucuronidase from Roseburia hominis
Descriptor: Beta-galactosidase, CALCIUM ION, FLAVIN MONONUCLEOTIDE
Authors:Pellock, S.J, Redinbo, M.R.
Deposit date:2018-10-25
Release date:2019-01-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery and Characterization of FMN-Binding beta-Glucuronidases in the Human Gut Microbiome.
J. Mol. Biol., 431, 2019
6MVF
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BU of 6mvf by Molmil
Crystal structure of FMN-binding beta-glucuronidase from Facaelibacterium prausnitzii L2-6
Descriptor: Beta-galactosidase/beta-glucuronidase, FLAVIN MONONUCLEOTIDE
Authors:Pellock, S.J, Redinbo, M.R.
Deposit date:2018-10-25
Release date:2019-01-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery and Characterization of FMN-Binding beta-Glucuronidases in the Human Gut Microbiome.
J. Mol. Biol., 431, 2019
8SBG
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BU of 8sbg by Molmil
Crystal structure of B. theta tryptophanase in holo form
Descriptor: PYRIDOXAL-5'-PHOSPHATE, Tryptophanase
Authors:Graboski, A.L, Redinbo, M.R.
Deposit date:2023-04-03
Release date:2023-08-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.
Cell Chem Biol, 30, 2023
8SIJ
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BU of 8sij by Molmil
Crystal structure of F. varium tryptophanase
Descriptor: CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE, Tryptophanase 1, ...
Authors:Graboski, A.L, Redinbo, M.R.
Deposit date:2023-04-16
Release date:2023-08-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.
Cell Chem Biol, 30, 2023
8SL7
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BU of 8sl7 by Molmil
Butyricicoccus sp. BIOML-A1 tryptophanase complex with (3S) ALG-05
Descriptor: (E)-3-[(3S)-3-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-alanine, Tryptophanase
Authors:Graboski, A.L, Redinbo, M.R.
Deposit date:2023-04-21
Release date:2023-08-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.
Cell Chem Biol, 30, 2023
7SVH
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BU of 7svh by Molmil
Bile Salt Hydrolase B from Lactobacillus gasseri
Descriptor: Choloylglycine hydrolase, MAGNESIUM ION
Authors:Walker, M.E, Redinbo, M.R.
Deposit date:2021-11-19
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.
Nat Microbiol, 8, 2023

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