3LPG

Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 3-(2-fluorophenyl)-1-(2-hydroxyethyl)-1-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea

Summary for 3LPG

Entry DOI	10.2210/pdb3lpg/pdb
Related	3K46 3K4A 3K4D 3LPF
Descriptor	Beta-glucuronidase, 3-(2-fluorophenyl)-1-(2-hydroxyethyl)-1-[(6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]urea (3 entities in total)
Functional Keywords	alpha/beta barrel, sugar-binding domain, beta-sandwich domain, glycosyl hydrolase, glycosidase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	139451.98
Authors	Wallace, B.D.,Redinbo, M.R. (deposition date: 2010-02-05, release date: 2010-11-17, Last modification date: 2023-11-22)
Primary citation	Wallace, B.D.,Wang, H.,Lane, K.T.,Scott, J.E.,Orans, J.,Koo, J.S.,Venkatesh, M.,Jobin, C.,Yeh, L.A.,Mani, S.,Redinbo, M.R. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science, 330:831-835, 2010 Cited by PubMed: 21051639 DOI: 10.1126/science.1191175 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.425 Å)

Structure validation