3LPF

Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea

Summary for 3LPF

• Entry DOI: 10.2210/pdb3lpf/pdb
• Related: 3K46 3K4A 3K4D 3LPG
• Descriptor: Beta-glucuronidase, 1-[(6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea (3 entities in total)
• Functional Keywords: alpha/beta barrel, sugar-binding domain, beta-sandwich domain, glycosyl hydrolase, beta-glucuronidase inhibitor, glycosidase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 139536.24

Authors

Wallace, B.D.,Redinbo, M.R. (deposition date: 2010-02-05, release date: 2010-11-17, Last modification date: 2023-11-22)

• Primary citation: Wallace, B.D.,Wang, H.,Lane, K.T.,Scott, J.E.,Orans, J.,Koo, J.S.,Venkatesh, M.,Jobin, C.,Yeh, L.A.,Mani, S.,Redinbo, M.R.; Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.; Science, 330:831-835, 2010; PubMed: 21051639; DOI: 10.1126/science.1191175

Experimental method

X-RAY DIFFRACTION (2.26 Å)