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1RLW
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BU of 1rlw by Molmil
CALCIUM-PHOSPHOLIPID BINDING DOMAIN FROM CYTOSOLIC PHOSPHOLIPASE A2
Descriptor: CADMIUM ION, CALCIUM ION, PHOSPHOLIPASE A2
Authors:Perisic, O, Williams, R.L.
Deposit date:1997-10-28
Release date:1998-02-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2.
J.Biol.Chem., 273, 1998
1H6H
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BU of 1h6h by Molmil
Structure of the PX domain from p40phox bound to phosphatidylinositol 3-phosphate
Descriptor: 2-(BUTANOYLOXY)-1-{[(HYDROXY{[2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL)OXY]METHYL}ETHYL BUTANOATE, GLYCEROL, NEUTROPHIL CYTOSOL FACTOR 4
Authors:Karathanassis, D, Bravo, J, Pacold, M, Perisic, O, Williams, R.L.
Deposit date:2001-06-15
Release date:2001-11-01
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of the Px Domain from P40Phox Bound to Phosphatidylinositol 3-Phosphate
Mol.Cell, 8, 2001
7BL1
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BU of 7bl1 by Molmil
human complex II-BATS bound to membrane-attached Rab5a-GTP
Descriptor: Beclin-1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Tremel, S, Morado, D.R, Kovtun, O, Williams, R.L, Briggs, J.A.G, Munro, S, Ohashi, Y, Bertram, J, Perisic, O.
Deposit date:2021-01-17
Release date:2021-03-03
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (9.8 Å)
Cite:Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes.
Nat Commun, 12, 2021
4D0L
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BU of 4d0l by Molmil
Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, ...
Authors:Burke, J.E, Inglis, A.J, Perisic, O, Masson, G.R, McLaughin, S.H, Rutaganira, F, Shokat, K.M, Williams, R.L.
Deposit date:2014-04-29
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors.
Science, 344, 2014
4D0M
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BU of 4d0m by Molmil
Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, ...
Authors:Burke, J.E, Inglis, A.J, Perisic, O, Masson, G.R, McLaughlin, S.H, Rutaganira, F, Shokat, K.M, Williams, R.L.
Deposit date:2014-04-29
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (6 Å)
Cite:Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors.
Science, 344, 2014
1W7P
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BU of 1w7p by Molmil
The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36)
Descriptor: VPS22, YPL002C, VPS25, ...
Authors:Teo, H, Perisic, O, Gonzalez, B, Williams, R.L.
Deposit date:2004-09-07
Release date:2004-09-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Escrt-II, an Endosome-Associated Complex Required for Protein Sorting: Crystal Structure and Interactions with Escrt-III and Membranes
Dev.Cell, 7, 2004
2X6F
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BU of 2x6f by Molmil
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH 3-METHYLADENINE
Descriptor: 6-AMINO-3-METHYLPURINE, PHOSPHOTIDYLINOSITOL 3 KINASE 59F
Authors:Miller, S, Tavshanjian, B, Oleksy, A, Perisic, O, Houseman, B.T, Shokat, K.M, Williams, R.L.
Deposit date:2010-02-17
Release date:2010-04-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.
Science, 327, 2010
2X6J
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BU of 2x6j by Molmil
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-93
Descriptor: N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, PHOSPHOTIDYLINOSITOL 3 KINASE 59F
Authors:Miller, S, Tavshanjian, B, Oleksy, A, Perisic, O, Houseman, B.T, Shokat, K.M, Williams, R.L.
Deposit date:2010-02-17
Release date:2010-04-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.
Science, 327, 2010
6SB0
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BU of 6sb0 by Molmil
cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ...
Authors:Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L.
Deposit date:2019-07-18
Release date:2019-10-16
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
7OWG
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BU of 7owg by Molmil
human DEPTOR in a complex with mutant human mTORC1 A1459P
Descriptor: DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ...
Authors:Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L.
Deposit date:2021-06-18
Release date:2021-09-08
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.
Elife, 10, 2021
2Y3A
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BU of 2y3a by Molmil
Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941
Descriptor: 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
Authors:Zhang, X, Vadas, O, Perisic, O, Williams, R.L.
Deposit date:2010-12-20
Release date:2011-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism.
Mol.Cell, 41, 2011
5KC2
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BU of 5kc2 by Molmil
Negative stain structure of Vps15/Vps34 complex
Descriptor: Phosphatidylinositol 3-kinase VPS34, Serine/threonine-protein kinase VPS15
Authors:Kirsten, M.L, Zhang, L, Ohashi, Y, Perisic, O, Williams, R.L, Sachse, C.
Deposit date:2016-06-04
Release date:2016-10-05
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (28 Å)
Cite:Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex.
Autophagy, 12, 2016
5KC1
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BU of 5kc1 by Molmil
Structure of the C-terminal dimerization domain of Atg38
Descriptor: 1,2-ETHANEDIOL, AMMONIUM ION, Autophagy-related protein 38, ...
Authors:Ohashi, Y, Soler, N, Garcia-Ortegon, M, Zhang, L, Perisic, O, Masson, G.R, Johnson, C.M, Williams, R.J.
Deposit date:2016-06-04
Release date:2016-10-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex.
Autophagy, 12, 2016
2CAY
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BU of 2cay by Molmil
Vps36 N-terminal PH domain
Descriptor: SULFATE ION, VACUOLAR PROTEIN SORTING PROTEIN 36
Authors:Teo, H, Williams, R.L, Perisic, O, Gill, D.J.
Deposit date:2005-12-23
Release date:2006-04-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Escrt-I Core and Escrt-II Glue Domain Structures Reveal Role for Glue in Linking to Escrt-I and Membranes.
Cell(Cambridge,Mass.), 125, 2006
2CAZ
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BU of 2caz by Molmil
ESCRT-I core
Descriptor: PROTEIN SRN2, SUPPRESSOR PROTEIN STP22 OF TEMPERATURE-SENSITIVE ALPHA-FACTOR RECEPTOR AND ARGININE PERMEASE, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS28
Authors:Gill, D.J, Teo, H, Sun, J, Perisic, O, Veprintsev, D.B, Vallis, Y, Emr, S.D, Williams, R.L.
Deposit date:2005-12-23
Release date:2006-04-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Escrt-I Core and Escrt-II Glue Domain Structures Reveal Role for Glue in Linking to Escrt-I and Membranes.
Cell(Cambridge,Mass.), 125, 2006
2YMB
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BU of 2ymb by Molmil
Structures of MITD1
Descriptor: CHARGED MULTIVESICULAR BODY PROTEIN 1A, MIT DOMAIN-CONTAINING PROTEIN 1
Authors:Hadders, M.A, Agromayor, M, Obita, T, Perisic, O, Caballe, A, Kloc, M, Lamers, M.H, Williams, R.L, Martin-Serrano, J.
Deposit date:2012-10-08
Release date:2012-10-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.404 Å)
Cite:Escrt-III Binding Protein Mitd1 is Involved in Cytokinesis and Has an Unanticipated Pld Fold that Binds Membranes.
Proc.Natl.Acad.Sci.USA, 109, 2012
8RCK
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BU of 8rck by Molmil
CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused on one protomer copy.
Descriptor: Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Anandapadamanaban, M, Hay, I.M, Perisic, O, Williams, R.L.
Deposit date:2023-12-06
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused on one protomer copy.
To Be Published
8RCN
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BU of 8rcn by Molmil
CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused region of mTOR and RAPTOR on one protomer copy.
Descriptor: Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Anandapadamanaban, M, Hay, I.M, Perisic, O, Williams, R.L.
Deposit date:2023-12-06
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused region of mTOR and RAPTOR on one protomer copy.
To Be Published
8RCH
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BU of 8rch by Molmil
CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, overall refinement
Descriptor: Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Anandapadamanaban, M, Hay, I.M, Perisic, O, Williams, R.L.
Deposit date:2023-12-06
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (4 Å)
Cite:cryoEM structure of mTORC1 with the cancer-associated 1455-EWED-1458 duplication variant, overall refinement
To Be Published
1UPT
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BU of 1upt by Molmil
Structure of a complex of the golgin-245 GRIP domain with Arl1
Descriptor: ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1, GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A MEMBER 4, ...
Authors:Panic, B, Perisic, O, Veprintsev, D.B, Williams, R.L, Munro, S.
Deposit date:2003-10-12
Release date:2003-10-30
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for Arl1-Dependent Targeting of Homodimeric Grip Domains to the Golgi Apparatus
Mol.Cell, 12, 2003
6S6D
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BU of 6s6d by Molmil
Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L.
Deposit date:2019-07-02
Release date:2019-10-16
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
6S6A
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BU of 6s6a by Molmil
Crystal structure of RagA-Q66L/RagC-T90N GTPase heterodimer complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L.
Deposit date:2019-07-02
Release date:2019-10-16
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
6SB2
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BU of 6sb2 by Molmil
cryo-EM structure of mTORC1 bound to active RagA/C GTPases
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ...
Authors:Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L.
Deposit date:2019-07-18
Release date:2019-10-16
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
4AE4
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BU of 4ae4 by Molmil
The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a novel SOUBA domain
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, POTASSIUM ION, ...
Authors:Agromayor, M, Soler, N, Caballe, A, Kueck, T, Freund, S.M, Allen, M.D, Bycroft, M, Perisic, O, Ye, Y, McDonald, B, Scheel, H, Hofmann, K, Neil, S.J.D, Martin-Serrano, J, Williams, R.L.
Deposit date:2012-01-06
Release date:2012-03-21
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.
Structure, 20, 2012
4A5X
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BU of 4a5x by Molmil
Structures of MITD1
Descriptor: 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, CHARGED MULTIVESICULAR BODY PROTEIN 1A, GLYCEROL, ...
Authors:Hadders, M.A, Agromayor, M, Caballe, A, Obita, T, Perisic, O, Williams, R.L, Martin-Serrano, J.
Deposit date:2011-10-28
Release date:2012-11-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Escrt-III Binding Protein Mitd1 is Involved in Cytokinesis and Has an Unanticipated Pld Fold that Binds Membranes.
Proc.Natl.Acad.Sci.USA, 109, 2012

 

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