2X6J

THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-93

Summary for 2X6J

Related2X6K 2X6H 2X6F 2X6I
DescriptorPHOSPHOTIDYLINOSITOL 3 KINASE 59F, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE (2 entities in total)
Functional Keywordstransferase
Biological sourceDROSOPHILA MELANOGASTER (FRUIT FLY)
Total number of polymer chains2
Total molecular weight158310.69
Authors
Miller, S.,Tavshanjian, B.,Oleksy, A.,Perisic, O.,Houseman, B.T.,Shokat, K.M.,Williams, R.L. (deposition date: 2010-02-17, release date: 2010-04-07, Last modification date: 2018-01-24)
Primary citation
Miller, S.,Tavshanjian, B.,Oleksy, A.,Perisic, O.,Houseman, B.T.,Shokat, K.M.,Williams, R.L.
Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.
Science, 327:1638-, 2010
PubMed: 20339072 (PDB entries with the same primary citation)
DOI: 10.1126/SCIENCE.1184429
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.263390.6%19.1%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload