2X6K

THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PI-103

Summary for 2X6K

Entry DOI	10.2210/pdb2x6k/pdb
Related	2X6F 2X6H 2X6I 2X6J
Descriptor	PHOSPHOTIDYLINOSITOL 3 KINASE 59F, SULFATE ION, 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL (3 entities in total)
Functional Keywords	pi103, pi-103, autophagy, transferase, pi3k class iii, phosphoinositide 3-kinase class iii
Biological source	DROSOPHILA MELANOGASTER (FRUIT FLY)
Total number of polymer chains	2
Total formula weight	158515.84
Authors	Miller, S.,Tavshanjian, B.,Oleksy, A.,Perisic, O.,Houseman, B.T.,Shokat, K.M.,Williams, R.L. (deposition date: 2010-02-17, release date: 2010-04-07, Last modification date: 2023-12-20)
Primary citation	Miller, S.,Tavshanjian, B.,Oleksy, A.,Perisic, O.,Houseman, B.T.,Shokat, K.M.,Williams, R.L. Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34. Science, 327:1638-, 2010 Cited by PubMed: 20339072 DOI: 10.1126/SCIENCE.1184429 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation