2X6K

THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PI-103

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	PHOSPHOTIDYLINOSITOL 3 KINASE 59F	polymer	696	78765.5	2	UniProt (Q9W1M7) Pfam (PF00613) Pfam (PF00454)	DROSOPHILA MELANOGASTER (FRUIT FLY)	GH13170P, VPS34
2	C, D, G (A, B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
3	E, F (A, B)	3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL	non-polymer		348.4	2	Chemie (X6K)

Sequence modifications

A, B: 254 - 257 (PDB: 2X6K)
A, B: 258 - 949 (UniProt: Q9W1M7)

PDB	External Database	Details
Ala 455	Gly 455	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	157530.9
Non-Polymers*	Number of molecules	5
	Total formula weight	984.9
All*	Total formula weight	158515.8

*Water molecules are not included.