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5L57
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CRYSTAL STRUCTURE OF ISO-CITRATE DEHYDROGENASE R132H IN COMPLEX WITH A NOVEL INHIBITOR (COMPOUND 13A)
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (1~{R},5~{S})-3-[6-(3-methylbutoxy)-5-[[(1~{R},3~{S})-5-oxidanyl-2-adamantyl]carbamoyl]pyridin-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid
Authors:Levy, C.
Deposit date:2016-05-28
Release date:2016-12-14
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (2.695 Å)
Cite:Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
J. Med. Chem., 59, 2016
5L58
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CRYSTAL STRUCTURE OF ISO-CITRATE DEHYDROGENASE 1 [IDH1 (R132H)] IN COMPLEX WITH A NOVEL INHIBITOR (COMPOUND 2)
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(3~{R})-1-[6-cyclohexylsulfanyl-5-[[(1~{R},3~{S})-5-oxidanyl-2-adamantyl]carbamoyl]pyridin-2-yl]pyrrolidin-3-yl]ethanoic acid
Authors:Levy, C.
Deposit date:2016-05-28
Release date:2016-12-14
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
J. Med. Chem., 59, 2016
2VWU
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EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4, N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine
Authors:Read, J., Brassington, C.A., Green, I., McCall, E.J., Valentine, A.L., Barratt, D., Rowsell, S., Packer, M., McAlister, M.
Deposit date:2008-06-27
Release date:2008-07-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines
Bioorg.Med.Chem.Lett., 18, 2008
4Z8Y
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CRYSTAL STRUCTURE OF RAB GTPASE SEC4P MUTANT - S29V
Descriptor:Ras-related protein SEC4, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Rinadi, F.C., Collins, R.N.
Deposit date:2015-04-09
Release date:2015-10-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:New insights into the molecular mechanism of the Rab GTPase Sec4p activation.
Bmc Struct.Biol., 15, 2015
4ZDW
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CRYSTAL STRUCTURE OF THE RAB GTPASE SEC4P MUTANT - S29V IN COMPLEX WITH SEC2P AND GDP
Descriptor:Ras-related protein SEC4, Rab guanine nucleotide exchange factor SEC2, GUANOSINE-5'-DIPHOSPHATE
Authors:Rinadi, F.C., Collins, R.N.
Deposit date:2015-04-20
Release date:2015-10-14
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:New insights into the molecular mechanism of the Rab GTPase Sec4p activation.
Bmc Struct.Biol., 15, 2015