2VWU

ephB4 kinase domain inhibitor complex

Summary for 2VWU

Related2BBA 2VWV 2VWY 2VWW 2VWX 2VWZ 2VX0 2VX1
DescriptorEPHRIN TYPE-B RECEPTOR 4, N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine (3 entities in total)
Functional Keywordstyrosine-protein kinase, receptor tyrosine kinase, kinase, mutant, membrane, receptor, transferase, atp-binding, polymorphism, glycoprotein, transmembrane, phosphoprotein, unphosphorylated, nucleotide-binding
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight34405.77
Authors
Read, J.,Brassington, C.A.,Green, I.,McCall, E.J.,Valentine, A.L.,Barratt, D.,Rowsell, S.,Packer, M.,McAlister, M. (deposition date: 2008-06-27, release date: 2008-07-08, Last modification date: 2019-05-08)
Primary citation
Bardelle, C.,Cross, D.,Davenport, S.,Kettle, J.G.,Ko, E.J.,Leach, A.G.,Mortlock, A.,Read, J.,Roberts, N.J.,Robins, P.,Williams, E.J.
Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines
Bioorg.Med.Chem.Lett., 18:2776-, 2008
PubMed: 18434142 (PDB entries with the same primary citation)
DOI: 10.1016/J.BMCL.2008.04.015
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2422 0.4%0 4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution