2VWZ
ephB4 kinase domain inhibitor complex
Summary for 2VWZ
Entry DOI | 10.2210/pdb2vwz/pdb |
Related | 2BBA 2VWV 2VWW 2VWX 2VWY 2VX0 2VX1 |
Descriptor | EPHRIN TYPE-B RECEPTOR 4, N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | tyrosine-protein kinase, receptor tyrosine kinase, kinase, mutant, membrane, receptor, transferase, atp-binding, polymorphism, glycoprotein, transmembrane, phosphoprotein, unphosphorylated, nucleotide-binding |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 34441.60 |
Authors | Read, J.,Brassington, C.A.,Green, I.,McCall, E.J.,Valentine, A.L.,Barratt, D.,Leach, A.G.,Kettle, J.G. (deposition date: 2008-06-30, release date: 2008-10-28, Last modification date: 2023-12-13) |
Primary citation | Bardelle, C.,Coleman, T.,Cross, D.,Davenport, S.,Kettle, J.G.,Ko, E.J.,Leach, A.G.,Mortlock, A.,Read, J.,Roberts, N.J.,Robins, P.,Williams, E.J. Inhibitors of the Tyrosine Kinase Ephb4. Part 2: Structure-Based Discovery and Optimisation of 3,5-Bis Substituted Anilinopyrimidines. Bioorg.Med.Chem.Lett., 18:5717-, 2008 Cited by PubMed: 18851911DOI: 10.1016/J.BMCL.2008.09.087 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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