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2VWZ

ephB4 kinase domain inhibitor complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 7X6 A 1889
ChainResidue
AILE621
AGLU697
AGLY699
ALEU747
AHOH2026
AHOH2249
AHOH2250
AHOH2251
AHOH2253
AALA645
ALYS647
AGLU664
AILE677
AILE691
ATHR693
AGLU694
AMET696

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 1890
ChainResidue
AASP740
AASP758
AMG1891
AHOH2113
AHOH2124
AHOH2125
AHOH2126

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 1891
ChainResidue
AASP740
AASP758
AMG1890
AHOH2112
AHOH2125
AHOH2128

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 1892
ChainResidue
AHOH2087
AHOH2088
AHOH2164
AHOH2165

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues27
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGAGEFGEVCrGrlkapgkkesc.......VAIK
ChainResidueDetails
AILE621-LYS647

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLAARNILV
ChainResidueDetails
ATYR736-VAL748

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
AASP740

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE621
ALYS647

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER769
ASER770

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AARG744
AASP740

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP740
AALA742

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP740
AASN745
AALA742

237735

PDB entries from 2025-06-18

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