9F9K

Crystal structure of MUS81-EME1 bound by compound 15.

This is a non-PDB format compatible entry.

Summary for 9F9K

• Entry DOI: 10.2210/pdb9f9k/pdb
• Related: 9F98 9F99 9F9A
• Descriptor: Crossover junction endonuclease MUS81, Crossover junction endonuclease EME1, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: endonuclease, fragment, drug discovery, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 141273.36

Authors

Collie, G.W. (deposition date: 2024-05-07, release date: 2024-07-03)

• Primary citation: Collie, G.W.,Borjesson, U.,Chen, Y.,Dong, Z.,Di Fruscia, P.,Gohlke, A.,Hoyle, A.,Hunt, T.A.,Jesani, M.H.,Luo, H.,Luptak, J.,Milbradt, A.G.,Narasimhan, P.,Packer, M.,Patel, S.,Qiao, J.,Storer, R.I.,Stubbs, C.J.,Tart, J.,Truman, C.,Wang, A.T.,Wheeler, M.G.,Winter-Holt, J.; Fragment-Based Discovery of Novel MUS81 Inhibitors; Acs Med.Chem.Lett., 2024; DOI: 10.1021/acsmedchemlett.3c00453

Experimental method

X-RAY DIFFRACTION (2.728 Å)