4Z8Y

Crystal structure of Rab GTPase Sec4p mutant - S29V

Summary for 4Z8Y

• Entry DOI: 10.2210/pdb4z8y/pdb
• Descriptor: Ras-related protein SEC4, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: gtpase, gdp bound, rab, gtp binding protein
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
• Cellular location: Cytoplasmic vesicle, secretory vesicle membrane; Lipid-anchor; Cytoplasmic side: P07560
• Total number of polymer chains: 2
• Total formula weight: 39401.02

Authors

Rinadi, F.C.,Collins, R.N. (deposition date: 2015-04-09, release date: 2015-10-14, Last modification date: 2023-09-27)

Primary citation

Rinaldi, F.C.,Packer, M.,Collins, R.
New insights into the molecular mechanism of the Rab GTPase Sec4p activation.
Bmc Struct.Biol., 15:14-14, 2015

PubMed Abstract: Sec4p is a small monomeric Ras-related GTP-binding protein (23 kDa) that regulates polarized exocytosis in S. cerevisiae. In this study we examine the structural effects of a conserved serine residue in the P-loop corresponding to G12 in Ras.

PubMed: 26263895
DOI: 10.1186/s12900-015-0041-5

Experimental method

X-RAY DIFFRACTION (1.9 Å)