Author results

2B1G
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CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE
分子名称:Bifunctional purine biosynthesis protein PURH, PHOSPHATE ION, POTASSIUM ION, ...
著者Xu, L., Chong, Y., Hwang, I., D'Onofrio, A., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
登録日2005-09-15
公開日2006-11-21
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.
J.Biol.Chem., 282, 2007
2B1I
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CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE
分子名称:Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, [3,4-DIHYDROXY-5R-(2,2,4-TRIOXO-1,2R,3S,4R-TETRAHYDRO-2L6-IMIDAZO[4,5-C][1,2,6]THIADIAZIN-7-YL)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATE
著者Xu, L., Chong, Y., Hwang, I., D'Onofrio, A., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
登録日2005-09-15
公開日2006-11-21
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.
J.Biol.Chem., 282, 2007
2IU0
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CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE
分子名称:BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH, POTASSIUM ION, 1,5-DIHYDROIMIDAZO[4,5-C][1,2,6]THIADIAZIN-4(3H)-ONE 2,2-DIOXIDE
著者Xu, L., Chong, Y., Hwang, I., Onofrio, A.D., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
登録日2006-05-26
公開日2007-02-20
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structure-Based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase
J.Biol.Chem., 282, 2007
2IU3
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CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE
分子名称:BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH, POTASSIUM ION, 1,5-DIHYDROIMIDAZO[4,5-C][1,2,6]THIADIAZIN-4(3H)-ONE 2,2-DIOXIDE
著者Xu, L., Chong, Y., Hwang, I., D'Onofrio, A., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
登録日2006-05-27
公開日2007-02-20
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase.
J. Biol. Chem., 282, 2007
1G5X
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THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I
分子名称:BETA-KETOACYL ACYL CARRIER PROTEIN SYNTHASE I
著者Zhang, Y.M., Rao, M.S., Heath, R.J., Price, A.C., Olson, A.J., Rock, C.O., White, S.W.
登録日2000-11-02
公開日2000-11-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III.
J.Biol.Chem., 276, 2001
1NJS
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HUMAN GAR TFASE IN COMPLEX WITH HYDROLYZED FORM OF 10-TRIFLUOROACETYL-5,10-DIDEAZA-ACYCLIC-5,6,7,8-TETRAHYDROFOLIC ACID
分子名称:Phosphoribosylglycinamide formyltransferase, PHOSPHATE ION, N-{4-[(1R)-4-[(2R,4R,5S)-2,4-DIAMINO-6-OXOHEXAHYDROPYRIMIDIN-5-YL]-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYL)BUTYL]BENZOYL}-D-GLUTAMIC ACID
著者Zhang, Y., Desharnais, J., Marsilje, T.H., Li, C., Hedrick, M.P., Gooljarsingh, L.T., Tavassoli, A., Benkovic, S.J., Olson, A.J., Boger, D.L., Wilson, I.A.
登録日2003-01-02
公開日2003-06-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Rational Design, Synthesis, Evaluation, and Crystal Structure of a Potent Inhibitor of Human GAR Tfase: 10-(Trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic Acid
Biochemistry, 42, 2003
1THZ
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CRYSTAL STRUCTURE OF AVIAN AICAR TRANSFORMYLASE IN COMPLEX WITH A NOVEL INHIBITOR IDENTIFIED BY VIRTUAL LIGAND SCREENING
分子名称:Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, 2-{(E)-[5-HYDROXY-3-METHYL-1-(2-METHYL-4-SULFOPHENYL)-1H-PYRAZOL-4-YL]DIAZENYL}-4-SULFOBENZOIC ACID
著者Xu, L., Li, C., Olson, A.J., Wilson, I.A.
登録日2004-06-01
公開日2004-09-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.
J.Biol.Chem., 279, 2004
1UM4
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CATALYTIC ANTIBODY 21H3 WITH HAPTEN
分子名称:Antibody 21H3 L chain, Antibody 21H3 H chain, (1R)-1-PHENYLETHYL 4-(ACETYLAMINO)BENZYLPHOSPHONATE
著者Beuscher IV, A.E., Reuter, J., Olson, A.J., Romesberg, F.E., Schultz, P.G., Wirsching, P., Janda, K.D., Lerner, R.A., Stevens, R.C.
登録日2003-09-23
公開日2004-10-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Studies of an Efficient Catalytic Antibody Operating by Ping-Pong and Induced Fit Mechanisms
To be Published
1UM5
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CATALYTIC ANTIBODY 21H3 WITH ALCOHOL SUBSTRATE
分子名称:Antibody 21H3 L chain, Antibody 21H3 H chain, 1-PHENYLETHANOL
著者Beuscher IV, A.E., Reuter, J., Olson, A.J., Romesberg, F.E., Schultz, P.G., Wirsching, P., Janda, K.D., Lerner, R.A., Stevens, R.C.
登録日2003-09-23
公開日2004-10-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Studies of an Efficient Catalytic Antibody Operating by Ping-Pong and Induced Fit Mechanisms
To be Published
1UM6
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CATALYTIC ANTIBODY 21H3
分子名称:antibody 21h3, L chain, H chain
著者Beuscher IV, A.E., Reuter, J., Olson, A.J., Romesberg, F.E., Schultz, P.G., Wirsching, P., Janda, K.D., Lerner, R.A., Stevens, R.C.
登録日2003-09-23
公開日2004-10-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Studies of an Efficient Catalytic Antibody Operating by Ping-Pong and Induced Fit Mechanisms
To be Published
1Z23
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THE SERINE-RICH DOMAIN FROM CRK-ASSOCIATED SUBSTRATE (P130CAS)
分子名称:CRK-associated substrate
著者Briknarova, K., Nasertorabi, F., Havert, M.L., Eggleston, E., Hoyt, D.W., Li, C., Olson, A.J., Vuori, K., Ely, K.R.
登録日2005-03-07
公開日2005-04-05
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle.
J.Biol.Chem., 280, 2005
1ZP8
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HIV PROTEASE WITH INHIBITOR AB-2
分子名称:Pol polyprotein, [1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL (1R,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YLCARBAMATE
著者Brik, A., Alexandratos, J.N., Elder, J.H., Olson, A.J., Wlodawer, A., Goodsell, D.S., Wong, C.H.
登録日2005-05-16
公開日2005-06-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors.
Chembiochem, 6, 2005
1ZPA
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HIV PROTEASE WITH SCRIPPS AB-3 INHIBITOR
分子名称:Pol polyprotein, TERT-BUTYL 4-[({[1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL}AMINO)CARBONYL]BENZYLCARBAMATE
著者Brik, A., Alexandratos, J., Lin, Y.C., Elder, J.H., Olson, A.J., Wlodawer, A., Goodsell, D.S., Wong, C.H.
登録日2005-05-16
公開日2005-05-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors
Chembiochem, 6, 2005
2A25
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CRYSTAL STRUCTURE OF SIAH1 SBD BOUND TO THE PEPTIDE EKPAAVVAPITTG FROM SIP
分子名称:Ubiquitin ligase SIAH1, Calcyclin-binding protein peptide, ZINC ION
著者Santelli, E., Leone, M., Li, C., Fukushima, T., Preece, N.E., Olson, A.J., Ely, K.R., Reed, J.C., Pellecchia, M., Liddington, R.C., Matsuzawa, S.
登録日2005-06-21
公開日2005-08-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex
J.Biol.Chem., 280, 2005
2A26
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CRYSTAL STRUCTURE OF THE N-TERMINAL, DIMERIZATION DOMAIN OF SIAH INTERACTING PROTEIN
分子名称:Calcyclin-binding protein, SULFATE ION, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID
著者Santelli, E., Leone, M., Li, C., Fukushima, T., Preece, N.E., Olson, A.J., Ely, K.R., Reed, J.C., Pellecchia, M., Liddington, R.C., Matsuzawa, S.
登録日2005-06-21
公開日2005-08-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex
J.Biol.Chem., 280, 2005
3TLH
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR
分子名称:PROTEIN (PROTEASE), benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
著者Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
登録日1998-12-03
公開日1998-12-09
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
5FIV
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR
分子名称:RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
著者Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
登録日1998-12-02
公開日1998-12-09
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
6FIV
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR
分子名称:RETROPEPSIN, SULFATE ION, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
著者Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
登録日1998-12-02
公開日1998-12-09
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
1B11
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STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH TL-3-093
分子名称:PROTEIN (Feline Immunodeficiency Virus PROTEASE), SULFATE ION, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
著者Gustchina, A., Li, M., Wlodawer, A.
登録日1998-11-25
公開日1998-12-02
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
1M8D
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INDUCIBLE NITRIC OXIDE SYNTHASE WITH CHLORZOXAZONE BOUND
分子名称:Inducible Nitric Oxide Synthase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
登録日2002-07-24
公開日2002-08-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M8E
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INDUCIBLE NITRIC OXIDE SYNTHASE WITH 7-NITROINDAZOLE BOUND
分子名称:inducible Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
著者Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
登録日2002-07-24
公開日2002-08-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M8H
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INDUCIBLE NITRIC OXIDE SYNTHASE WITH 6-NITROINDAZOLE BOUND
分子名称:inducible Nitric oxide synthase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
登録日2002-07-24
公開日2002-08-07
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M8I
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INDUCIBLE NITRIC OXIDE SYNTHASE WITH 5-NITROINDAZOLE BOUND
分子名称:inducible Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
著者Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
登録日2002-07-24
公開日2002-08-07
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9J
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HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH CHLORZOXAZONE BOUND
分子名称:endothelial Nitric-oxide synthase, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
登録日2002-07-29
公開日2002-08-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9K
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HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH 7-NITROINDAZOLE BOUND
分子名称:endothelial Nitric-oxide synthase, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
登録日2002-07-29
公開日2002-08-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
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