1THZ
Crystal Structure of Avian AICAR Transformylase in Complex with a Novel Inhibitor Identified by Virtual Ligand Screening
Summary for 1THZ
Entry DOI | 10.2210/pdb1thz/pdb |
Related | 1G8M 1M9N 1OZ0 1P4R 1PKX 1PL0 |
Descriptor | Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, 2-{(E)-[5-HYDROXY-3-METHYL-1-(2-METHYL-4-SULFOPHENYL)-1H-PYRAZOL-4-YL]DIAZENYL}-4-SULFOBENZOIC ACID, ... (4 entities in total) |
Functional Keywords | atic, virtual ligand screening, purine biosynthesis, cancer target, transferase, hydrolase |
Biological source | Gallus gallus (chicken) |
Total number of polymer chains | 2 |
Total formula weight | 130066.54 |
Authors | Xu, L.,Li, C.,Olson, A.J.,Wilson, I.A. (deposition date: 2004-06-01, release date: 2004-09-07, Last modification date: 2023-08-23) |
Primary citation | Xu, L.,Li, C.,Olson, A.J.,Wilson, I.A. Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. J.Biol.Chem., 279:50555-50565, 2004 Cited by PubMed: 15355974DOI: 10.1074/jbc.M406801200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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