1ZPA

HIV Protease with Scripps AB-3 Inhibitor

Summary for 1ZPA

• Entry DOI: 10.2210/pdb1zpa/pdb
• Related: 1ZP8
• Descriptor: Pol polyprotein, TERT-BUTYL 4-[({[1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL}AMINO)CARBONYL]BENZYLCARBAMATE (3 entities in total)
• Functional Keywords: protease, retroviral, hydrolase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 11525.69

Authors

Brik, A.,Alexandratos, J.,Lin, Y.C.,Elder, J.H.,Olson, A.J.,Wlodawer, A.,Goodsell, D.S.,Wong, C.H. (deposition date: 2005-05-16, release date: 2005-05-31, Last modification date: 2024-04-03)

• Primary citation: Brik, A.,Alexandratos, J.,Lin, Y.C.,Elder, J.H.,Olson, A.J.,Wlodawer, A.,Goodsell, D.S.,Wong, C.H.; 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors; Chembiochem, 6:1167-1169, 2005; PubMed: 15934050; DOI: 10.1002/cbic.200500101

Experimental method

X-RAY DIFFRACTION (2.02 Å)