2IU0
crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase
Replaces: 2B0WSummary for 2IU0
Entry DOI | 10.2210/pdb2iu0/pdb |
Descriptor | BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH, POTASSIUM ION, 1,5-DIHYDROIMIDAZO[4,5-C][1,2,6]THIADIAZIN-4(3H)-ONE 2,2-DIOXIDE, ... (4 entities in total) |
Functional Keywords | multifunctional enzyme, transition state analogue, atic, impch, hydrolase, inhibitor, transferase, structure-base, purine biosynthesis |
Biological source | GALLUS GALLUS (CHICKEN) |
Total number of polymer chains | 2 |
Total formula weight | 129261.77 |
Authors | Xu, L.,Chong, Y.,Hwang, I.,Onofrio, A.D.,Amore, K.,Beardsley, G.P.,Li, C.,Olson, A.J.,Boger, D.L.,Wilson, I.A. (deposition date: 2006-05-26, release date: 2007-02-20, Last modification date: 2023-12-13) |
Primary citation | Xu, L.,Chong, Y.,Hwang, I.,D'Onofrio, A.,Amore, K.,Beardsley, G.P.,Li, C.,Olson, A.J.,Boger, D.L.,Wilson, I.A. Structure-Based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase J.Biol.Chem., 282:13033-, 2007 Cited by PubMed: 17324932DOI: 10.1074/JBC.M607293200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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