4EJL

Apo HIV Protease (PR) dimer in closed form with fragment 1F1-N in the outside/top of flap

Summary for 4EJL

Entry DOI	10.2210/pdb4ejl/pdb
Related	4EJ8 4EJD 4EJK
Descriptor	Protease, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywords	apo protease, allostery, fragment binding, hydrolase
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12499
Total number of polymer chains	2
Total formula weight	22355.38
Authors	Tiefenbrunn, T.,Stout, C.D. (deposition date: 2012-04-06, release date: 2013-05-01, Last modification date: 2024-02-28)
Primary citation	Tiefenbrunn, T.,Forli, S.,Baksh, M.M.,Chang, M.W.,Happer, M.,Lin, Y.C.,Perryman, A.L.,Rhee, J.K.,Torbett, B.E.,Olson, A.J.,Elder, J.H.,Finn, M.G.,Stout, C.D. Small molecule regulation of protein conformation by binding in the Flap of HIV protease. Acs Chem.Biol., 8:1223-1231, 2013 Cited by PubMed: 23540839 DOI: 10.1021/cb300611p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.445 Å)

Structure validation