2IU3

Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase

Summary for 2IU3

• Entry DOI: 10.2210/pdb2iu3/pdb
• Related: 1G8M 1M9N 1OZ0 1THZ 2IU0
• Descriptor: BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH, POTASSIUM ION, 1,5-DIHYDROIMIDAZO[4,5-C][1,2,6]THIADIAZIN-4(3H)-ONE 2,2-DIOXIDE, ... (4 entities in total)
• Functional Keywords: multifunctional enzyme, transition state analogue, atic, impch, hydrolase, inhibitor, transferase, structure-base, purine biosynthesis
• Biological source: GALLUS GALLUS (CHICKEN)
• Total number of polymer chains: 2
• Total formula weight: 129261.77

Authors

Xu, L.,Chong, Y.,Hwang, I.,D'Onofrio, A.,Amore, K.,Beardsley, G.P.,Li, C.,Olson, A.J.,Boger, D.L.,Wilson, I.A. (deposition date: 2006-05-27, release date: 2007-02-20, Last modification date: 2023-12-13)

• Primary citation: Xu, L.,Chong, Y.,Hwang, I.,D'Onofrio, A.,Amore, K.,Beardsley, G.P.,Li, C.,Olson, A.J.,Boger, D.L.,Wilson, I.A.; Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase.; J. Biol. Chem., 282:13033-13046, 2007; PubMed: 17324932; DOI: 10.1074/jbc.M607293200

Experimental method

X-RAY DIFFRACTION (2.9 Å)