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2V5L
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BU of 2v5l by Molmil
Structures of the Open and Closed State of Trypanosomal Triosephosphate Isomerase: as Observed in a New Crystal Form: Implications for the Reaction Mechanism
Descriptor: SULFATE ION, TRIOSEPHOSPHATE ISOMERASE
Authors:Noble, M.E.M, Zeelen, J.P, Wierenga, R.K.
Deposit date:2007-07-06
Release date:2007-07-31
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the Open and Closed State of Trypanosomal Triosephosphate Isomerase: As Observed in a New Crystal Form: Implications for the Reaction Mechanism
Proteins: Struct.,Funct., Genet., 16, 1993
6TIM
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BU of 6tim by Molmil
THE ADAPTABILITY OF THE ACTIVE SITE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AS OBSERVED IN THE CRYSTAL STRUCTURES OF THREE DIFFERENT COMPLEXES
Descriptor: SN-GLYCEROL-3-PHOSPHATE, TRIOSEPHOSPHATE ISOMERASE
Authors:Noble, M.E.M, Wierenga, R.K, Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes.
Proteins, 10, 1991
1VIN
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BU of 1vin by Molmil
BOVINE CYCLIN A3
Descriptor: CYCLIN A
Authors:Noble, M.E.M, Endicott, J.A.E, Brown, N.R.
Deposit date:1996-03-15
Release date:1996-08-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of cyclin A.
Structure, 3, 1995
8ROZ
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BU of 8roz by Molmil
Cryo-EM structure of CDK2-cyclin A in complex with CDC25A
Descriptor: Cyclin-A2, Cyclin-dependent kinase 2, M-phase inducer phosphatase 1
Authors:Rowland, R.J, Noble, M.E.M, Endicott, J.A.
Deposit date:2024-01-12
Release date:2024-05-29
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM structure of the CDK2-cyclin A-CDC25A complex.
Nat Commun, 15, 2024
6SG4
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BU of 6sg4 by Molmil
Structure of CDK2/cyclin A M246Q, S247EN
Descriptor: Cyclin-A2, Cyclin-dependent kinase 2
Authors:Salamina, M, Basle, A, Massa, B, Noble, M.E.M, Endicott, J.A.
Deposit date:2019-08-02
Release date:2021-01-27
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.
J.Mol.Biol., 433, 2021
2CCH
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BU of 2cch by Molmil
The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, CELL DIVISION PROTEIN KINASE 2, ...
Authors:Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition
J.Biol.Chem., 281, 2006
7OZT
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BU of 7ozt by Molmil
Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a
Descriptor: Camelid nanobody NB09, Cyclin-dependent kinase inhibitor 2A
Authors:Pastok, M.W, Burbidge, O, Itzhaki, L, Endicott, J.A, Noble, M.E.M.
Deposit date:2021-06-28
Release date:2022-07-13
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a
To Be Published
7QUM
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BU of 7qum by Molmil
ATAD2 in complex with FragLite2
Descriptor: 1,2-ETHANEDIOL, 4-IODOPYRAZOLE, ATPase family AAA domain-containing protein 2, ...
Authors:Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M.
Deposit date:2022-01-18
Release date:2023-03-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
7QZM
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BU of 7qzm by Molmil
ATAD2 in complex with FragLite28
Descriptor: 1,2-ETHANEDIOL, 4-bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one, ATPase family AAA domain-containing protein 2, ...
Authors:Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M.
Deposit date:2022-01-31
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
7QZY
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BU of 7qzy by Molmil
ATAD2 in complex with FragLite29
Descriptor: 1,2-ETHANEDIOL, 4-bromanyl-1-(2-methoxyethyl)pyridin-2-one, ATPase family AAA domain-containing protein 2, ...
Authors:Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M.
Deposit date:2022-02-01
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
7QYK
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BU of 7qyk by Molmil
ATAD2 in complex with FragLite18
Descriptor: (4-bromanylpyridin-2-yl)methanol, 1,2-ETHANEDIOL, ATPase family AAA domain-containing protein 2, ...
Authors:Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M.
Deposit date:2022-01-28
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
1OW6
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BU of 1ow6 by Molmil
Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase
Descriptor: Focal adhesion kinase 1, Paxillin
Authors:Hoellerer, M.K, Noble, M.E.M, Labesse, G, Campbell, I.D, Werner, J.M, Arold, S.T.
Deposit date:2003-03-28
Release date:2003-10-21
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular Recognition of Paxillin LD motifs by the Focal Adhesion Targeting Domain
Structure, 11, 2003
5LRQ
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BU of 5lrq by Molmil
BRD4 in complex with ERK5 inhibitor XMD8-92
Descriptor: 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 4
Authors:Martin, M.P, Noble, M.E.M.
Deposit date:2016-08-19
Release date:2017-08-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38 alpha and BRD4.
Eur.J.Med.Chem., 178, 2019
2VF2
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BU of 2vf2 by Molmil
X-ray crystal structure of HsaD from Mycobacterium tuberculosis
Descriptor: 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD, GLYCEROL, SULFATE ION
Authors:Lack, N, Lowe, E.D, Liu, J, Eltis, L.D, Noble, M.E.M, Sim, E, Westwood, I.M.
Deposit date:2007-10-29
Release date:2007-11-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of Hsad, a Steroid-Degrading Hydrolase, from Mycobacterium Tuberculosis.
Acta Crystallogr.,Sect.F, 64, 2008
2VFC
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BU of 2vfc by Molmil
The structure of Mycobacterium marinum arylamine N-acetyltransferase in complex with CoA
Descriptor: ARYLAMINE N-ACETYLTRANSFERASE, COENZYME A
Authors:Fullam, E, Westwood, I.M, Anderton, M.C, Lowe, E.D, Sim, E, Noble, M.E.M.
Deposit date:2007-11-02
Release date:2007-12-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Divergence of Cofactor Recognition Across Evolution: Coenzyme a Binding in a Prokaryotic Arylamine N-Acetyltransferase.
J.Mol.Biol., 375, 2008
2V9C
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BU of 2v9c by Molmil
X-ray Crystallographic Structure of a Pseudomonas aeruginosa Azoreductase in Complex with Methyl Red.
Descriptor: 2-(4-DIMETHYLAMINOPHENYL)DIAZENYLBENZOIC ACID, FLAVIN MONONUCLEOTIDE, FMN-DEPENDENT NADH-AZOREDUCTASE 1, ...
Authors:Wang, C.-J, Hagemeier, C, Rahman, N, Lowe, E.D, Noble, M.E.M, Coughtrie, M, Sim, E, Westwood, I.M.
Deposit date:2007-08-23
Release date:2007-11-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Molecular Cloning, Characterisation and Ligand- Bound Structure of an Azoreductase from Pseudomonas Aeruginosa
J.Mol.Biol., 373, 2007
2VFB
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BU of 2vfb by Molmil
The structure of Mycobacterium marinum arylamine N-acetyltransferase
Descriptor: ARYLAMINE N-ACETYLTRANSFERASE
Authors:Fullam, E, Westwood, I.M, Anderton, M.C, Lowe, E.D, Sim, E, Noble, M.E.M.
Deposit date:2007-11-02
Release date:2007-12-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Divergence of Cofactor Recognition Across Evolution: Coenzyme a Binding in a Prokaryotic Arylamine N-Acetyltransferase.
J.Mol.Biol., 375, 2008
8BYL
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BU of 8byl by Molmil
Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex
Descriptor: Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, S-phase kinase-associated protein 1, ...
Authors:Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E.M.
Deposit date:2022-12-13
Release date:2023-06-28
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1.
Sci Rep, 13, 2023
2WMA
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BU of 2wma by Molmil
Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIC RKLFN-NH2, CYCLIN-A2
Authors:Robertson, G.F, Endicott, J.A, Noble, M.E.M, McDonnell, J.M.
Deposit date:2009-06-30
Release date:2010-09-01
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and Thermodynamic Consequences of Cyclization of Peptide Ligands for the Recruitment Site of Cyclin A
To be Published
2WMB
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BU of 2wmb by Molmil
Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, LINEAR RKLFD, ...
Authors:Robertson, G.F, Endicott, J.A, Noble, M.E.M, McDonnell, J.M.
Deposit date:2009-06-30
Release date:2010-09-01
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and Thermodynamic Consequences of Cyclization of Peptide Ligands for the Recruitment Site of Cyclin A
To be Published
2VZC
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BU of 2vzc by Molmil
Crystal structure of the C-terminal calponin homology domain of alpha parvin
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Lorenz, S, Vakonakis, I, Lowe, E.D, Campbell, I.D, Noble, M.E.M, Hoellerer, M.K.
Deposit date:2008-07-31
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Structural Analysis of the Interactions between Paxillin Ld Motifs and Alpha-Parvin
Structure, 16, 2008
1QL6
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BU of 1ql6 by Molmil
THE CATALYTIC MECHANISM OF PHOSPHORYLASE KINASE PROBED BY MUTATIONAL STUDIES
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PHOSPHORYLASE KINASE, ...
Authors:Skamnaki, V.T, Owen, D.J, Noble, M.E.M, Lowe, E.D, Oikonomakos, N.G, Johnson, L.N.
Deposit date:1999-08-24
Release date:1999-12-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies.
Biochemistry, 38, 1999
2VZD
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BU of 2vzd by Molmil
Crystal structure of the C-terminal calponin homology domain of alpha parvin in complex with paxillin LD1 motif
Descriptor: 1,2-ETHANEDIOL, ALPHA-PARVIN, GLYCEROL, ...
Authors:Lorenz, S, Vakonakis, I, Lowe, E.D, Campbell, I.D, Noble, M.E.M, Hoellerer, M.K.
Deposit date:2008-07-31
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis of the Interactions between Paxillin Ld Motifs and Alpha-Parvin
Structure, 16, 2008
1H24
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BU of 1h24 by Molmil
CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, TRANSCRIPTION FACTOR E2F1
Authors:Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H28
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BU of 1h28 by Molmil
CDK2/CyclinA in complex with an 11-residue recruitment peptide from p107
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-LIKE PROTEIN 1
Authors:Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002

238582

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