7OZT

Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a

This is a non-PDB format compatible entry.

Summary for 7OZT

• Entry DOI: 10.2210/pdb7ozt/pdb
• Descriptor: Camelid nanobody NB09, Cyclin-dependent kinase inhibitor 2A (3 entities in total)
• Functional Keywords: nanobody-p16ink4a complex, tumour-suppressor, checkpoint, pharmacological chaperone, cell cycle
• Biological source: Lama glama (Llama); More
• Total number of polymer chains: 2
• Total formula weight: 32909.82

Authors

Pastok, M.W.,Burbidge, O.,Itzhaki, L.,Endicott, J.A.,Noble, M.E.M. (deposition date: 2021-06-28, release date: 2022-07-13, Last modification date: 2024-10-23)

• Primary citation: Burbidge, O.,Pastok, M.W.,Hodder, S.L.,Zenkeviciute, G.,Noble, M.E.M.,Endicott, J.A.,Itzhaki, L.; Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.74 Å)