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2V5L
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STRUCTURES OF THE OPEN AND CLOSED STATE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE: AS OBSERVED IN A NEW CRYSTAL FORM: IMPLICATIONS FOR THE REACTION MECHANISM
Descriptor:TRIOSEPHOSPHATE ISOMERASE, SULFATE ION
Authors:Noble, M.E.M., Zeelen, J.P., Wierenga, R.K.
Deposit date:2007-07-06
Release date:2007-07-31
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the Open and Closed State of Trypanosomal Triosephosphate Isomerase: As Observed in a New Crystal Form: Implications for the Reaction Mechanism
Proteins: Struct.,Funct., Genet., 16, 1993
6TIM
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THE ADAPTABILITY OF THE ACTIVE SITE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AS OBSERVED IN THE CRYSTAL STRUCTURES OF THREE DIFFERENT COMPLEXES
Descriptor:TRIOSEPHOSPHATE ISOMERASE, SN-GLYCEROL-3-PHOSPHATE
Authors:Noble, M.E.M., Wierenga, R.K., Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes.
Proteins, 10, 1991
1VIN
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BOVINE CYCLIN A3
Descriptor:CYCLIN A
Authors:Noble, M.E.M., Endicott, J.A.E., Brown, N.R.
Deposit date:1996-03-15
Release date:1996-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of cyclin A.
Structure, 3, 1995
1H24
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CDK2/CYCLINA IN COMPLEX WITH A 9 RESIDUE RECRUITMENT PEPTIDE FROM E2F
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, TRANSCRIPTION FACTOR E2F1
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H25
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CDK2/CYCLIN A IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM RETINOBLASTOMA-ASSOCIATED PROTEIN
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-ASSOCIATED PROTEIN
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H26
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CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P53
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CELLULAR TUMOR ANTIGEN P53
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H27
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CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P27
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CYCLIN-DEPENDENT KINASE INHIBITOR 1B
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H28
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CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P107
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-LIKE PROTEIN 1
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1OW6
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PAXILLIN LD4 MOTIF BOUND TO THE FOCAL ADHESION TARGETING (FAT) DOMAIN OF THE FOCAL ADHESION KINASE
Descriptor:Focal adhesion kinase 1, Paxillin
Authors:Hoellerer, M.K., Noble, M.E.M., Labesse, G., Campbell, I.D., Werner, J.M., Arold, S.T.
Deposit date:2003-03-28
Release date:2003-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular Recognition of Paxillin LD motifs by the Focal Adhesion Targeting Domain
Structure, 11, 2003
1E2T
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ARYLAMINE N-ACETYLTRANSFERASE (NAT) FROM SALMONELLA TYPHIMURIUM
Descriptor:N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE
Authors:Sinclair, J.C., Sandy, J., Delgoda, R., Sim, E., Noble, M.E.M.
Deposit date:2000-05-24
Release date:2000-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Arylamine N-Acetyltransferase Reveals a Catalytic Triad
Nat.Struct.Biol., 7, 2000
1E1V
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU2058
Descriptor:CYCLIN-DEPENDENT PROTEIN KINASE 2, 6-O-CYCLOHEXYLMETHYL GUANINE
Authors:Endicott, J.A., Noble, M.E.M., Johnson, L.N.
Deposit date:2000-05-11
Release date:2001-05-10
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles.
J.Med.Chem., 43, 2000
1E1X
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU6027
Descriptor:CYCLIN-DEPENDENT PROTEIN KINASE 2, 6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE
Authors:Endicott, J.A., Noble, M.E.M., Johnson, L.N.
Deposit date:2000-05-11
Release date:2001-05-10
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles.
J.Med.Chem., 43, 2000
1H0V
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HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 2-AMINO-6-[(R)-PYRROLIDINO-5'-YL]METHOXYPURINE
Descriptor:CELL DIVISION PROTEIN KINASE 2, 5-{[(2-AMINO-9H-PURIN-6-YL)OXY]METHYL}-2-PYRROLIDINONE
Authors:Gibson, A.E., Arris, C.E., Bentley, J., Boyle, F.T., Curtin, N.J., Davies, T.G., Endicott, J.A., Golding, B.T., Grant, S., Griffin, R.J., Jewsbury, P., Johnson, L.N., Mesguiche, V., Newell, D.R., Noble, M.E.M., Tucker, J.A., Whitfield, H.J.
Deposit date:2002-06-27
Release date:2003-06-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O(6)-Substituted Guanine Derivatives
J.Med.Chem., 45, 2002
1H0W
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HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 2-AMINO-6-[CYCLOHEX-3-ENYL]METHOXYPURINE
Descriptor:CELL DIVISION PROTEIN KINASE 2, 1-AMINO-6-CYCLOHEX-3-ENYLMETHYLOXYPURINE
Authors:Gibson, A.E., Arris, C.E., Bentley, J., Boyle, F.T., Curtin, N.J., Davies, T.G., Endicott, J.A., Golding, B.T., Grant, S., Griffin, R.J., Jewsbury, P., Johnson, L.N., Mesguiche, V., Newell, D.R., Noble, M.E.M., Tucker, J.A., Whitfield, H.J.
Deposit date:2002-06-27
Release date:2003-06-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O(6)-Substituted Guanine Derivatives
J.Med.Chem., 45, 2002
1H1P
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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU2058
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, 6-O-CYCLOHEXYLMETHYL GUANINE
Authors:Davies, T.G., Noble, M.E.M., Endicott, J.A., Johnson, L.N.
Deposit date:2002-07-21
Release date:2002-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Based Design of a Potent Purine-Based Cyclin-Dependent Kinase Inhibitor
Nat.Struct.Biol., 9, 2002
1H1Q
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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU6094
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE
Authors:Davies, T.G., Noble, M.E.M., Endicott, J.A., Johnson, L.N.
Deposit date:2002-07-21
Release date:2002-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Based Design of a Potent Purine-Based Cyclin-Dependent Kinase Inhibitor
Nat.Struct.Biol., 9, 2002
1H1S
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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU6102
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE
Authors:Davies, T.G., Noble, M.E.M., Endicott, J.A., Johnson, L.N.
Deposit date:2002-07-21
Release date:2002-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Design of a Potent Purine-Based Cyclin-Dependent Kinase Inhibitor
Nat.Struct.Biol., 9, 2002
1OGU
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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 2-ARYLAMINO-4-CYCLOHEXYLMETHYL-5-NITROSO-6-AMINOPYRIMIDINE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, 4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDE, ...
Authors:Pratt, D.J., Endicott, J.A., Noble, M.E.M.
Deposit date:2003-05-13
Release date:2003-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Based Design of 2-Arylamino-4-Cyclohexyl Methyl-5-Nitroso-6-Aminopyrimidine Inhibitors of Cyclin-Dependent Kinases 1 and 2
Bioorg.Med.Chem.Lett., 13, 2003
1OI9
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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 6-CYCLOHEXYLMETHYLOXY-2-ANILINO-PURINE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, 6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE, ...
Authors:Pratt, D.J., Endicott, J.A., Noble, M.E.M.
Deposit date:2003-06-10
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2
J.Med.Chem., 47, 2004
1OIU
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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 6-CYCLOHEXYLMETHYLOXY-2-ANILINO-PURINE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, 3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE, ...
Authors:Pratt, D.J., Endicott, J.A., Noble, M.E.M.
Deposit date:2003-06-26
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2
J.Med.Chem., 47, 2004
1OIY
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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 6-CYCLOHEXYLMETHYLOXY-2-ANILINO-PURINE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, 4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE, ...
Authors:Pratt, D.J., Endicott, J.A., Noble, M.E.M.
Deposit date:2003-06-26
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2
J.Med.Chem., 47, 2004
1OW7
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PAXILLIN LD4 MOTIF BOUND TO THE FOCAL ADHESION TARGETING (FAT) DOMAIN OF THE FOCAL ADHESION KINASE
Descriptor:Focal adhesion kinase 1, Paxillin
Authors:Hoellerer, M.K., Noble, M.E.M., Labesse, G., Werner, J.M., Arold, S.T.
Deposit date:2003-03-28
Release date:2003-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Recognition of Paxillin LD Motifs by the Focal Adhesion Targeting Domain
Structure, 11, 2003
1OW8
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PAXILLIN LD2 MOTIF BOUND TO THE FOCAL ADHESION TARGETING (FAT) DOMAIN OF THE FOCAL ADHESION KINASE
Descriptor:Focal adhesion kinase 1, Paxillin
Authors:Hoellerer, M.K., Noble, M.E.M., Labesse, G., Werner, J.M., Arold, S.T.
Deposit date:2003-03-28
Release date:2003-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Molecular Recognition of Paxillin LD Motifs by the Focal Adhesion Targeting Domain
Structure, 11, 2003
1W5R
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X-RAY CRYSTALLOGRAPHIC STRCUTURE OF A C70Q MYCOBACTERIUM SMEGMATIS N- ARYLAMINE ACETYLTRANSFERASE
Descriptor:ARYLAMINE N-ACETYLTRANSFERASE
Authors:Holton, S.J., Sandy, J., Rodrigues-Lima, F., Dupret, J.-M., Bhakta, S., Noble, M.E.M., Sim, E.
Deposit date:2004-08-09
Release date:2005-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Investigation of the Catalytic Triad of Arylamine N-Acetyltransferases: Essential Residues Required for Acetyl Transfer to Arylamines.
Biochem.J., 390, 2005
1W6F
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ARYLAMINE N-ACETYLTRANSFERASE FROM MYCOBACTERIUM SMEGMATIS WITH THE ANTI-TUBERCULAR DRUG ISONIAZID BOUND IN THE ACTIVE SITE.
Descriptor:ARYLAMINE N-ACETYLTRANSFERASE, 4-(DIAZENYLCARBONYL)PYRIDINE
Authors:Sandy, J., Holton, S., Fullham, E., Sim, E., Noble, M.E.M.
Deposit date:2004-08-17
Release date:2005-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binding of the Anti-Tubercular Drug Isoniazid to the Arylamine N-Acetyltransferase Protein from Mycobacterium Smegmatis
Protein Sci., 14, 2005