Author results

2VD6
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HUMAN ADENYLOSUCCINATE LYASE IN COMPLEX WITH ITS SUBSTRATE N6-(1,2- DICARBOXYETHYL)-AMP, AND ITS PRODUCTS AMP AND FUMARATE.
Descriptor:ADENYLOSUCCINATE LYASE, ADENOSINE MONOPHOSPHATE, FUMARIC ACID, ...
Authors:Stenmark, P., Moche, M., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Dahlgren, L.G., Edwards, A., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg-schiavone, L., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Lehtio, L., Nilsson, M., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Thorsell, A.G., Tresaugues, L., van den Berg, S., Weigelt, J., Welin, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2007-09-30
Release date:2007-10-23
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human Adenylosuccinate Lyase in Complex with its Substrate N6-(1,2-Dicarboxyethyl)-AMP, and its Products AMP and Fumarate.
To be Published
4UFO
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LABORATORY EVOLVED VARIANT R-C1B1D33E6 OF POTATO EPOXIDE HYDROLASE STEH1
Descriptor:EPOXIDE HYDROLASE
Authors:Carlsson, A.J., Bauer, P., Nilsson, M., Dobritzsch, D., Kamerlin, S.C.L., Widersten, M.
Deposit date:2015-03-17
Release date:2016-04-13
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Laboratory Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme-Catalyzed Epoxide Hydrolysis.
Chembiochem, 17, 2016
4UFP
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LABORATORY EVOLVED VARIANT R-C1B1D33 OF POTATO EPOXIDE HYDROLASE STEH1
Descriptor:EPOXIDE HYDROLASE
Authors:Carlsson, A.J., Bauer, P., Nilsson, M., Dobritzsch, D., Kamerlin, S.C.L., Widersten, M.
Deposit date:2015-03-17
Release date:2016-04-13
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Laboratory Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme-Catalyzed Epoxide Hydrolysis.
Chembiochem, 17, 2016
4AOW
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CRYSTAL STRUCTURE OF THE HUMAN RACK1 PROTEIN AT A RESOLUTION OF 2.45 ANGSTROM
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2-LIKE 1, GLYCEROL
Authors:Ruiz Carrillo, D., Chandrasekaran, R., Nilsson, M., Cornvick, T., Liew, C.W., Tan, S.M., Lescar, J.
Deposit date:2012-03-30
Release date:2012-08-08
Last modified:2012-08-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure of Human Rack1 Protein at a Resolution of 2.45 A.
Acta Crystallogr.,Sect.F, 68, 2012
3DA9
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CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH INHIBITOR
Descriptor:Thrombin light chain, Thrombin heavy chain, Hirudin peptide, ...
Authors:Xue, Y., Hansson, S.K.
Deposit date:2008-05-29
Release date:2009-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Compounds binding to the S2-S3 pockets of thrombin.
J.Med.Chem., 52, 2009
6GGH
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HUMAN JAK1 KINASE DOMAIN IN COMPLEX WITH INHIBITOR
Descriptor:Tyrosine-protein kinase JAK1, ~{N}-[5-methyl-4-[7-[[(2~{R})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{H}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide
Authors:Read, J.A., Augustin, M., Lammens, A.
Deposit date:2018-05-03
Release date:2019-05-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition of local lung inflammation by a potent and selective JAK1 inhibitor; activation of JAK1, but not JAK3, is critical to IL-4R mediated immune cell signalling
To Be Published
3FO5
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HUMAN START DOMAIN OF ACYL-COENZYME A THIOESTERASE 11 (ACOT11)
Descriptor:Thioesterase, adipose associated, isoform BFIT2, ...
Authors:Siponen, M.I., Lehtio, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nilsson, M.E., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Thorsell, A.G., Tresaugues, L., Van-Den-Berg, S., Weigelt, J., Welin, M., Wikstrom, M., Wisniewska, M., Shueler, H., Structural Genomics Consortium (SGC)
Deposit date:2008-12-27
Release date:2009-02-24
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comparative structural analysis of lipid binding START domains.
Plos One, 6, 2011
3P0L
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HUMAN STEROIDOGENIC ACUTE REGULATORY PROTEIN
Descriptor:Steroidogenic acute regulatory protein, mitochondrial
Authors:Lehtio, L., Siponen, M., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Herman, M.D., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Moche, M., Nilsson, M.E., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Sundstrom, M., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2010-09-29
Release date:2010-11-24
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Comparative structural analysis of lipid binding START domains.
Plos One, 6, 2011
4UHB
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LABORATORY EVOLVED VARIANT R-C1 OF POTATO EPOXIDE HYDROLASE STEH1
Descriptor:EPOXIDE HYDROLASE, GLYCEROL, 1,2-ETHANEDIOL
Authors:Nilsson, M.T.I., Carlsson, A.J., Dobritzsch, D., Widersten, M.
Deposit date:2015-03-23
Release date:2016-04-13
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Laboratory Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme-Catalyzed Epoxide Hydrolysis.
Chembiochem, 17, 2016
2PZ9
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CRYSTAL STRUCTURE OF PUTATIVE TRANSCRIPTIONAL REGULATOR SCO4942 FROM STREPTOMYCES COELICOLOR
Descriptor:Putative regulatory protein, SULFATE ION
Authors:Filippova, E.V., Chruszcz, M., Xu, X., Zheng, H., Cymborowski, M., Savchenko, A., Edwards, A., Joachimiak, A., Minor, W., Midwest Center for Structural Genomics (MCSG)
Deposit date:2007-05-17
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:In situ proteolysis for protein crystallization and structure determination.
Nat.Methods, 4, 2007
2PSO
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HUMAN STARD13 (DLC2) LIPID TRANSFER AND PROTEIN LOCALIZATION DOMAIN
Descriptor:StAR-related lipid transfer protein 13
Authors:Lehtio, L., Busam, R., Arrowsmith, C.H., Berglund, H., Collins, R., Dahlgren, L.G., Edwards, A., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg-Schiavone, L., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Moche, M., Nordlund, P., Nyman, T., Ogg, D., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., Van den Berg, S., Weigelt, J., Welin, M., Persson, C., Structural Genomics Consortium (SGC)
Deposit date:2007-05-07
Release date:2007-05-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Comparative structural analysis of lipid binding START domains.
Plos One, 6, 2011
2R55
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HUMAN STAR-RELATED LIPID TRANSFER PROTEIN 5
Descriptor:StAR-related lipid transfer protein 5
Authors:Lehtio, L., Busam, R.D., Arrowsmith, C.H., Berglund, H., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Herman, M.D., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Moche, M., Nordlund, P., Nyman, T., Sagemark, J., Sundstrom, M., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Persson, C., Structural Genomics Consortium (SGC)
Deposit date:2007-09-03
Release date:2007-09-18
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Comparative structural analysis of lipid binding START domains.
Plos One, 6, 2011
2UVL
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HUMAN BIR3 DOMAIN OF BACULOVIRAL INHIBITOR OF APOPTOSIS REPEAT- CONTAINING 3 (BIRC3)
Descriptor:BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 3, ZINC ION, GLYCEROL
Authors:Moche, M., Lehtio, L., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Dahlgren, L.G., Edwards, A., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg-Schiavone, L., Johansson, I., Karlberg, T., Kotenyova, T., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., Upsten, M., Van Den Berg, S., Weigelt, J., Nordlund, P.
Deposit date:2007-03-12
Release date:2007-03-27
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structures of Bir Domains from Human Naip and Ciap2.
Acta Crystallogr.,Sect.F, 65, 2009
3KEE
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HCV NS3/NS4A COMPLEXED WITH NON-COVALENT MACROCYCLIC COMPOUND TMC435
Descriptor:Genome polyprotein, 19-mer peptide from Genome polyprotein, (2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2-({7-methoxy-8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide, ...
Authors:Lindberg, J.D., Nystrom, S., Cummings, M.D.
Deposit date:2009-10-26
Release date:2010-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target
Angew.Chem.Int.Ed.Engl., 49, 2010
3KF2
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THE HCV NS3/NS4A PROTEASE APO STRUCTURE
Descriptor:Polyprotein, 19-mer peptide from Genome polyprotein, ZINC ION
Authors:Lindberg, J.D., Nystrom, S., Cummings, M.D.
Deposit date:2009-10-27
Release date:2010-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target
Angew.Chem.Int.Ed.Engl., 49, 2010
4UFN
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LABORATORY EVOLVED VARIANT R-C1B1 OF POTATO EPOXIDE HYDROLASE STEH1
Descriptor:EPOXIDE HYDROLASE, 1,4-DIETHYLENE DIOXIDE
Authors:Carlsson, A.J., Bauer, P., Nilsson, M., Dobritzsch, D., Kamerlin, S.C.L., Widersten, M.
Deposit date:2015-03-17
Release date:2016-04-13
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1.
Org.Biomol.Chem., 14, 2016
2P0X
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SOLUTION STRUCTURE OF A NON-BIOLOGICAL ATP-BINDING PROTEIN
Descriptor:abiotic ATP-binding, folding optimized protein, ZINC ION, ...
Authors:Mansy, S.S., Szostak, J.W., Chaput, J.C.
Deposit date:2007-03-01
Release date:2007-08-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Evolutionary Analysis of a Non-biological ATP-binding Protein
J.Mol.Biol., 371, 2007
4AMM
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CRYSTAL STRUCTURE OF THE ACYLTRANSFERASE DOMAIN OF THE ITERATIVE POLYKETIDE SYNTHASE IN ENEDIYNE BIOSYNTHESIS REVEALS THE MOLECULAR BASIS OF SUBSTRATE SPECIFICITY
Descriptor:DYNE8, CHLORIDE ION
Authors:Liew, C.W., Lescar, J.
Deposit date:2012-03-13
Release date:2012-05-23
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
J.Biol.Chem., 287, 2012
4AMN
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CRYSTAL STRUCTURE OF THE ACYLTRANSFERASE DOMAIN OF THE ITERATIVE POLYKETIDE SYNTHASE IN ENEDIYNE BIOSYNTHESIS REVEALS THE MOLECULAR BASIS OF SUBSTRATE SPECIFICITY
Descriptor:DYNE8, GLYCEROL, CHLORIDE ION
Authors:Liew, C.W., Lescar, J.
Deposit date:2012-03-13
Release date:2012-05-23
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
J.Biol.Chem., 287, 2012
4AMO
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CRYSTAL STRUCTURE OF THE ACYLTRANSFERASE DOMAIN OF THE ITERATIVE POLYKETIDE SYNTHASE IN ENEDIYNE BIOSYNTHESIS REVEALS THE MOLECULAR BASIS OF SUBSTRATE SPECIFICITY
Descriptor:DYNE8, ACETIC ACID
Authors:Liew, C.W., Lescar, J.
Deposit date:2012-03-13
Release date:2012-05-23
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
J.Biol.Chem., 287, 2012
4AMP
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CRYSTAL STRUCTURE OF THE ACYLTRANSFERASE DOMAIN OF THE ITERATIVE POLYKETIDE SYNTHASE IN ENEDIYNE BIOSYNTHESIS REVEALS THE MOLECULAR BASIS OF SUBSTRATE SPECIFICITY
Descriptor:DYNE8, CHLORIDE ION, MALONATE ION, ...
Authors:Liew, C.W., Lescar, J.
Deposit date:2012-03-13
Release date:2012-05-23
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
J.Biol.Chem., 287, 2012
4UWT
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HYPOCREA JECORINA CEL7A E212Q MUTANT IN COMPLEX WITH P-NITROPHENYL CELLOBIOSIDE
Descriptor:CELLOBIOHYDROLASE CEL7A, N-ACETYL-D-GLUCOSAMINE, COBALT (II) ION, ...
Authors:Nutt, A., Momeni, M.H., Johansson, G., Stahlberg, J.
Deposit date:2014-08-14
Release date:2015-08-26
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:O-Nitrophenyl Cellobioside as an Active Site Probe for Family 7 Cellobiohydrolases and Structural Insight to Unexpected Enzyme Kinetics on Nitrophenyl Disaccharide Substrates
To be Published
4V0Z
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O-NITROPHENYL CELLOBIOSIDE AS AN ACTIVE SITE PROBE FOR FAMILY 7 CELLOBIOHYDROLASES
Descriptor:CELLOBIOHYDROLASE CEL7A, N-ACETYL-D-GLUCOSAMINE, COBALT (II) ION, ...
Authors:Nutt, A., Momeni, M.H., Stahlberg, J.
Deposit date:2014-09-19
Release date:2015-09-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:O-Nitrophenyl Cellobioside as an Active Site Probe for Family 7 Cellobiohydrolases
To be Published