2VD6

Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate.

Summary for 2VD6

Related2J91
DescriptorADENYLOSUCCINATE LYASE, ADENOSINE MONOPHOSPHATE, FUMARIC ACID, ... (7 entities in total)
Functional Keywordspurine biosynthesis, lyase, epilepsy, purine metabolism
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains4
Total molecular weight231327.86
Authors
Primary citation
Stenmark, P.,Moche, M.,Arrowsmith, C.,Berglund, H.,Busam, R.,Collins, R.,Dahlgren, L.G.,Edwards, A.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hallberg, B.M.,Holmberg-Schiavone, L.,Johansson, I.,Kallas, A.,Karlberg, T.,Kotenyova, T.,Lehtio, L.,Nilsson, M.,Nyman, T.,Ogg, D.,Persson, C.,Sagemark, J.,Sundstrom, M.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Nordlund, P.
Human Adenylosuccinate Lyase in Complex with its Substrate N6-(1,2-Dicarboxyethyl)-AMP, and its Products AMP and Fumarate.
To be Published,
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23240.3%1.1%10.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2vd6
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Molmil generated image of 2vd6
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Molmil generated image of 2vd6
rotated about y axis by 90°