2VD6

Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	ADENYLOSUCCINATE LYASE	polymer	503	57191.5	4	UniProt (P30566) Pfam (PF00206) Pfam (PF10397)	HOMO SAPIENS (HUMAN)	ADENYLOSUCCINASE, ASL, ASASE
2	E, O (A, C)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP)
3	F, P (A, C)	FUMARIC ACID	non-polymer		116.1	2	Chemie (FUM)
4	G, K, L, Q, T (A, B, C, D)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
5	H, I, M, N, R... (A, B, C, D)	CHLORIDE ION	non-polymer		35.5	7	Chemie (CL)
6	J, S (B, D)	2-[9-(3,4-DIHYDROXY-5-PHOSPHONOOXYMETHYL-TETRAHYDRO-FURAN-2-YL)-9H-PURIN-6-YLAMINO]-SUCCINIC ACID	non-polymer		463.3	2	Chemie (2SA)
7	W, X, Y, Z (A, B, C, D)	water	water		18.0	880	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 481 (UniProt: P30566)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	228766.0
Non-Polymers*	Number of molecules	18
	Total formula weight	2561.8
All*	Total formula weight	231327.9

*Water molecules are not included.