2VD6
Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ADENYLOSUCCINATE LYASE | polymer | 503 | 57191.5 | 4 | UniProt (P30566) Pfam (PF00206) Pfam (PF10397) | HOMO SAPIENS (HUMAN) | ADENYLOSUCCINASE, ASL, ASASE |
| 2 | E, O (A, C) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) PubChem (224) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (5316444) PubChem (5742864) PubChem (12163610) PubChem (12358355) PubChem (16397049) PubChem (16760266) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (46875232) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (92144436) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (12358354) PubChem (122197642) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 3 | F, P (A, C) | FUMARIC ACID | non-polymer | 116.1 | 2 | Chemie (FUM) | |||
| 4 | G, K, L, Q, T (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) PubChem (753) | |||
| 5 | H, I, M, N, R... (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 7 | Chemie (CL) PubChem (312) | |||
| 6 | J, S (B, D) | 2-[9-(3,4-DIHYDROXY-5-PHOSPHONOOXYMETHYL-TETRAHYDRO-FURAN-2-YL)-9H-PURIN-6-YLAMINO]-SUCCINIC ACID | non-polymer | 463.3 | 2 | Chemie (2SA) PubChem (195) PubChem (447145) PubChem (440122) PubChem (132576807) PubChem (163069561) PubChem (154082314) PubChem (163069559) PubChem (163069560) PubChem (163069562) PubChem (166725382) PubChem (166725383) PubChem (168445226) | |||
| 7 | W, X, Y, Z (A, B, C, D) | water | water | 18.0 | 880 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 481 (UniProt: P30566)
| PDB | External Database | Details |
|---|---|---|
| Met -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| Ser -14 | - | expression tag |
| Ser -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Val -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Leu -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Thr -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 228766.0 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2561.8 | |
| All* | Total formula weight | 231327.9 |
