3P0L

Human steroidogenic acute regulatory protein

Summary for 3P0L

• Entry DOI: 10.2210/pdb3p0l/pdb
• Descriptor: Steroidogenic acute regulatory protein, mitochondrial (1 entity in total)
• Functional Keywords: structural genomics consortium, sgc, start domain, cholesterol transport, cholesterol, mitochondria, transport protein
• Biological source: Homo sapiens (human)
• Cellular location: Mitochondrion: P49675
• Total number of polymer chains: 4
• Total formula weight: 98821.57

Authors

Lehtio, L.,Siponen, M.,Arrowsmith, C.H.,Berglund, H.,Busam, R.D.,Collins, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hallberg, B.M.,Herman, M.D.,Johansson, A.,Johansson, I.,Kallas, A.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Sundstrom, M.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2010-09-29, release date: 2010-11-24, Last modification date: 2023-09-06)

Primary citation

Thorsell, A.G.,Lee, W.H.,Persson, C.,Siponen, M.I.,Nilsson, M.,Busam, R.D.,Kotenyova, T.,Schuler, H.,Lehtio, L.
Comparative structural analysis of lipid binding START domains.
Plos One, 6:e19521-e19521, 2011

PubMed Abstract: Steroidogenic acute regulatory (StAR) protein related lipid transfer (START) domains are small globular modules that form a cavity where lipids and lipid hormones bind. These domains can transport ligands to facilitate lipid exchange between biological membranes, and they have been postulated to modulate the activity of other domains of the protein in response to ligand binding. More than a dozen human genes encode START domains, and several of them are implicated in a disease.

PubMed: 21738568
DOI: 10.1371/journal.pone.0019521

Experimental method

X-RAY DIFFRACTION (3.4 Å)