3DA9
Crystal structure of thrombin in complex with inhibitor
Summary for 3DA9
Entry DOI | 10.2210/pdb3da9/pdb |
Descriptor | Thrombin light chain, Thrombin heavy chain, Hirudin peptide, ... (6 entities in total) |
Functional Keywords | thrombin, inhibitor complex, acute phase, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, pharmaceutical, polymorphism, protease, secreted, serine protease, zymogen |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 3 |
Total formula weight | 35457.33 |
Authors | Xue, Y.,Hansson, S.K. (deposition date: 2008-05-29, release date: 2009-05-19, Last modification date: 2024-04-03) |
Primary citation | Nilsson, M.,Hamalainen, M.,Ivarsson, M.,Gottfries, J.,Xue, Y.,Hansson, S.,Isaksson, R.,Fex, T. Compounds binding to the S2-S3 pockets of thrombin. J.Med.Chem., 52:2708-2715, 2009 Cited by PubMed: 19371038DOI: 10.1021/jm8011849 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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