Author results

1ZSD
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CRYSTAL STRUCTURE OF HLA-B*3501 PRESENTING AN 11-MER EBV ANTIGEN EPLPQGQLTAY
Descriptor:HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, ...
Authors:Miles, J.J., Elhassen, D., Borg, N.A., Silins, S.L., Tynan, F.E., Burrows, J.M., Purcell, A.W., Kjer-Nielsen, L., Rossjohn, J., Burrows, S.R., McCluskey, J.
Deposit date:2005-05-24
Release date:2005-06-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:CTL Recognition of a Bulged Viral Peptide Involves Biased TCR Selection.
J.Immunol., 175, 2005
2FYY
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THE ROLE OF T CELL RECEPTOR ALPHA GENES IN DIRECTING HUMAN MHC RESTRICTION
Descriptor:HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, ...
Authors:Miles, J.J., Borg, N.A.
Deposit date:2006-02-08
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:TCRalpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope
J.Immunol., 177, 2006
2FZ3
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THE ROLE OF T CELL RECEPTOR ALPHA GENES IN DIRECTING HUMAN MHC RESTRICTION
Descriptor:HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, ...
Authors:Miles, J.J., Borg, N.A.
Deposit date:2006-02-09
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:TCRalpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope
J.Immunol., 177, 2006
3O4L
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GENETIC AND STRUCTURAL BASIS FOR SELECTION OF A UBIQUITOUS T CELL RECEPTOR DEPLOYED IN EPSTEIN-BARR VIRUS
Descriptor:MHC class I antigen, Beta-2-microglobulin, BSLF2/BMLF1 protein, ...
Authors:Miles, J.J., Bulek, A.M., Cole, D.K., Gostick, E., Schauenburg, J.A., Dolton, G., Venturi, V., Davenport, M.P., Tan, M.P., Burrows, S.R., Wooldridge, L., Price, D.A., Rizkallah, P.J., Sewell, A.K.
Deposit date:2010-07-27
Release date:2011-01-12
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection.
Plos Pathog., 6, 2010
1ZHK
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CRYSTAL STRUCTURE OF HLA-B*3501 PRESENTING 13-MER EBV ANTIGEN LPEPLPQGQLTAY
Descriptor:HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, ...
Authors:Tynan, F.E., Borg, N.A., Miles, J.J., Beddoe, T., El-Hassen, D., Silins, S.L., van Zuylen, W.J., Purcell, A.W., Kjer-Nielsen, L., McCluskey, J., Burrows, S.R., Rossjohn, J.
Deposit date:2005-04-26
Release date:2005-05-17
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The high resolution structures of highly bulged viral epitopes bound to the major histocompatability class I: Implications for T-cell receptor engagement and T-cell immunodominance
J.Biol.Chem., 280, 2005
1ZHL
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CRYSTAL STRUCTURE OF HLA-B*3508 PRESENTING 13-MER EBV ANTIGEN LPEPLPQGQLTAY
Descriptor:HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, ...
Authors:Tynan, F.E., Borg, N.A., Miles, J.J., Beddoe, T., El-Hassen, D., Silins, S.L., van Zuylen, W.J., Purcell, A.W., Kjer-Nielsen, L., McCluskey, J., Burrows, S.R., Rossjohn, J.
Deposit date:2005-04-26
Release date:2005-05-17
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The high resolution structures of highly bulged viral epitopes bound to the major histocompatability class I: Implications for T-cell receptor engagement and T-cell immunodominance
J.Biol.Chem., 280, 2005
2AK4
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CRYSTAL STRUCTURE OF SB27 TCR IN COMPLEX WITH HLA-B*3508-13MER PEPTIDE
Descriptor:HLA-B35 variant, Beta-2-microglobulin, EBV peptide LPEPLPQGQLTAY, ...
Authors:Tynan, F.E., Burrows, S.R., Buckle, A.M., Clements, C.S., Borg, N.A., Miles, J.J., Beddoe, T., Whisstock, J.C., Wilce, M.C., Silins, S.L., Burrows, J.M., Kjer-Nielsen, L., Konstenko, L., Purcell, A.W., McCluskey, J., Rossjohn, J.
Deposit date:2005-08-03
Release date:2005-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide
Nat.Immunol., 6, 2005
2AXF
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THE IMMUNOGENICITY OF A VIRAL CYTOTOXIC T CELL EPITOPE IS CONTROLLED BY ITS MHC-BOUND CONFORMATION
Descriptor:HLA class I histocompatibility antigen, B*3508 heavy chain, Beta-2-microglobulin, ...
Authors:Tynan, F.E., Elhassen, D., Purcell, A.W., Burrows, J.M., Borg, N.A., Miles, J.J., Williamson, N.A., Green, K.J., Tellam, J., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J., Burrows, S.R.
Deposit date:2005-09-05
Release date:2005-11-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation
J.Exp.Med., 202, 2005
2AXG
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THE IMMUNOGENICITY OF A VIRAL CYTOTOXIC T CELL EPITOPE IS CONTROLLED BY ITS MHC-BOUND CONFORMATION
Descriptor:HLA class I histocompatibility antigen, B*3501 heavy chain, Beta-2-microglobulin, ...
Authors:Tynan, F.E., Elhassen, D., Purcell, A.W., Burrows, J.M., Borg, N.A., Miles, J.J., Williamson, N.A., Green, K.J., Tellam, J., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J., Burrows, S.R.
Deposit date:2005-09-05
Release date:2005-11-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation
J.Exp.Med., 202, 2005
3BW9
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CRYSTAL STRUCTURE OF HLA B*3508 IN COMPLEX WITH A HCMV 12-MER PEPTIDE FROM THE PP65 PROTEIN
Descriptor:HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, ...
Authors:Wynn, K.K., Marland, Z., Cooper, L., Silins, S.L., Gras, S., Archbold, J.K., Tynan, F.E., Miles, J.J., McCluskey, J., Burrows, S.R., Rossjohn, J., Khanna, R.
Deposit date:2008-01-08
Release date:2008-04-22
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection
Blood, 111, 2008
3BWA
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CRYSTAL STRUCTURE OF HLA B*3508 IN COMPLEX WITH A HCMV 8-MER PEPTIDE FROM THE PP65 PROTEIN
Descriptor:HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, ...
Authors:Wynn, K.K., Marland, Z., Cooper, L., Silins, S.L., Gras, S., Archbold, J.K., Tynan, F.E., Miles, J.J., McCluskey, J., Burrows, S.R., Rossjohn, J., Khanna, R.
Deposit date:2008-01-08
Release date:2008-04-22
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection
Blood, 111, 2008
3HG1
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GERMLINE-GOVERNED RECOGNITION OF A CANCER EPITOPE BY AN IMMUNODOMINANT HUMAN T CELL RECEPTOR
Descriptor:MHC class I antigen, Beta-2-microglobulin, CANCER/MART-1, ...
Authors:Cole, D.K., Yuan, F., Rizkallah, P.J., Miles, J.J., Gostick, E., Price, D.A., Gao, G.F., Jakobsen, B.K., Sewell, A.K.
Deposit date:2009-05-13
Release date:2009-07-28
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
J.Biol.Chem., 284, 2009
3MV7
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CRYSTAL STRUCTURE OF THE TK3 TCR IN COMPLEX WITH HLA-B*3501/HPVG
Descriptor:HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, ...
Authors:Gras, S., Chen, Z., Miles, J.J., Liu, Y.C., Bell, M.J., Sullivan, L.C., Kjer-Nielsen, L., Brennan, R.M., Burrows, J.M., Neller, M.A., Khanna, R., Purcell, A.W., Brooks, A.G., McCluskey, J., Rossjohn, J., Burrows, S.R.
Deposit date:2010-05-03
Release date:2010-06-09
Last modified:2011-07-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Allelic polymorphism in the T cell receptor and its impact on immune responses
J.Exp.Med., 207, 2010
3MV8
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CRYSTAL STRUCTURE OF THE TK3-GLN55HIS TCR IN COMPLEX WITH HLA-B*3501/HPVG
Descriptor:HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, ...
Authors:Gras, S., Chen, Z., Miles, J.J., Liu, Y.C., Bell, M.J., Sullivan, L.C., Kjer-Nielsen, L., Brennan, R.M., Burrows, J.M., Neller, M.A., Khanna, R., Purcell, A.W., Brooks, A.G., McCluskey, J., Rossjohn, J., Burrows, S.R.
Deposit date:2010-05-03
Release date:2010-06-09
Last modified:2011-07-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Allelic polymorphism in the T cell receptor and its impact on immune responses
J.Exp.Med., 207, 2010
3MV9
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CRYSTAL STRUCTURE OF THE TK3-GLN55ALA TCR IN COMPLEX WITH HLA-B*3501/HPVG
Descriptor:HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, ...
Authors:Gras, S., Chen, Z., Miles, J.J., Liu, Y.C., Bell, M.J., Sullivan, L.C., Kjer-Nielsen, L., Brennan, R.M., Burrows, J.M., Neller, M.A., Khanna, R., Purcell, A.W., Brooks, A.G., McCluskey, J., Rossjohn, J., Burrows, S.R.
Deposit date:2010-05-03
Release date:2010-06-09
Last modified:2011-07-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Allelic polymorphism in the T cell receptor and its impact on immune responses
J.Exp.Med., 207, 2010
4L4T
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STRUCTURE OF HUMAN MAIT TCR IN COMPLEX WITH HUMAN MR1-6-FP
Descriptor:Major histocompatibility complex class I-related gene protein, Beta-2-microglobulin, MAIT T-cell receptor alpha chain, ...
Authors:Patel, O., Kjer-Nielsen, L., Le Nours, J., Eckle, S.B.G., Birkinshaw, R.W., Beddoe, T., Corbett, A.J., Liu, L., Miles, J.J., Meehan, B., Reantragoon, R., Sandoval-Romero, M.L., Sullivan, L.C., Brooks, A.G., Chen, Z., Fairlie, D.P., McCluskey, J., Rossjohn, J.
Deposit date:2013-06-09
Release date:2013-07-17
Last modified:2013-09-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of vitamin B metabolites by mucosal-associated invariant T cells.
Nat Commun, 4, 2013
4L4V
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STRUCTURE OF HUMAN MAIT TCR IN COMPLEX WITH HUMAN MR1-RL-6-ME-7-OH
Descriptor:Major histocompatibility complex class I-related gene protein, Beta-2-microglobulin, MAIT T-cell receptor alpha chain, ...
Authors:Patel, O., Kjer-Nielsen, L., Le Nours, J., Eckle, S.B.G., Birkinshaw, R.W., Beddoe, T., Corbett, A.J., Liu, L., Miles, J.J., Meehan, B., Reantragoon, R., Sandoval-Romero, M.L., Sullivan, L.C., Brooks, A.G., Chen, Z., Fairlie, D.P., McCluskey, J., Rossjohn, J.
Deposit date:2013-06-09
Release date:2013-07-17
Last modified:2013-09-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recognition of vitamin B metabolites by mucosal-associated invariant T cells.
Nat Commun, 4, 2013
4I4W
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PEPTIDE LENGTH DETERMINES THE OUTCOME OF T CELL RECEPTOR/PEPTIDE-MHCI ENGAGEMENT
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Wooldridge, L., Cole, D.K.
Deposit date:2012-11-28
Release date:2013-01-02
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Peptide length determines the outcome of TCR/peptide-MHCI engagement.
Blood, 121, 2013
4JFD
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PRESERVATION OF PEPTIDE SPECIFICITY DURING TCR-MHC CONTACT DOMINATED AFFINITY ENHANCEMENT OF A MELANOMA-SPECIFIC TCR
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFE
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PRESERVATION OF PEPTIDE SPECIFICITY DURING TCR-MHC CONTACT DOMINATED AFFINITY ENHANCEMENT OF A MELANOMA-SPECIFIC TCR
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFF
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PRESERVATION OF PEPTIDE SPECIFICITY DURING TCR-MHC CONTACT DOMINATED AFFINITY ENHANCEMENT OF A MELANOMA-SPECIFIC TCR
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFH
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HIGH AFFINITY ALPHA24-BETA17 T CELL RECEPTOR FOR A2 HLA-MELANOMA PEPTIDE COMPLEX
Descriptor:alpha24 TCR allele, beta17 TCR allele, 1,2-ETHANEDIOL, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFO
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A2 HLA COMPLEX WITH E1A HETEROCLITIC VARIANT OF MELANOMA PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K., Baker, B.M.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFP
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A2 HLA COMPLEX WITH G4A HETEROCLITIC VARIANT OF MELANOMA PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFQ
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A2 HLA COMPLEX WITH L8A HETEROCLITIC VARIANT OF MELANOMA PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K., Baker, B.M.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013