5MEN

Human Leukocyte Antigen A02 presenting ILAKFLHWL, in complex with cognate T-Cell Receptor

Summary for 5MEN

Related5MEO 5MEP 5MEQ 5MER 4MNQ
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ILE-LEU-ALA-LYS-PHE-LEU-HIS-TRP-LEU, ... (9 entities in total)
Functional Keywordsimmuno, hla-a02, 1e6-tcr, cross-reactivity, immune system
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein P01892
Secreted . Note=(Microbial infection) In the presence of M P61769
Total number of polymer chains5
Total molecular weight94971.19
Authors
Rizkallah, P.J.,Lloyd, A.,Crowther, M.,Cole, D.K.,Sewell, A.K. (deposition date: 2016-11-16, release date: 2016-12-07, Last modification date: 2017-03-22)
Primary citation
Cole, D.K.,van den Berg, H.A.,Lloyd, A.,Crowther, M.D.,Beck, K.,Ekeruche-Makinde, J.,Miles, J.J.,Bulek, A.M.,Dolton, G.,Schauenburg, A.J.,Wall, A.,Fuller, A.,Clement, M.,Laugel, B.,Rizkallah, P.J.,Wooldridge, L.,Sewell, A.K.
Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
J. Biol. Chem., 292:802-813, 2017
PubMed: 27903649 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M116.741603
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.81 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19760.9%15.5%1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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