5MEN
Human Leukocyte Antigen A02 presenting ILAKFLHWL, in complex with cognate T-Cell Receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 276 | 31951.3 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (Human) | MHC class I antigen A*2 |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (C) | ILE-LEU-ALA-LYS-PHE-LEU-HIS-TRP-LEU | polymer | 9 | 1142.4 | 1 | UniProt (by SIFTS) (O14746) | Homo sapiens | |
| 4 | D (D) | Protein TRAV22,Human nkt tcr alpha chain | polymer | 200 | 22223.5 | 1 | UniProt (A0A0B4J277) UniProt (K7N5M3) Pfam (PF07686) Pfam (PF09291) | Homo sapiens (Human) | Human nkt tcr beta chain |
| 5 | E (E) | Protein TRBV6-5,Human nkt tcr beta chain | polymer | 240 | 26891.8 | 1 | UniProt (A0A0K0K1A5) UniProt (K7N5M4) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) | |
| 6 | F, G, L, M, N (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 7 | H (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | I, J, K, O, P (A, B, E) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 9 | Q, R, S, T, U (A, B, C, D, E) | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
B: 1 - 99 (UniProt: P61769)
D: 2 - 89 (UniProt: A0A0B4J277)
D: 113 - 201 (UniProt: K7N5M3)
E: 2 - 95 (UniProt: A0A0K0K1A5)
E: 117 - 241 (UniProt: K7N5M4)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Asp 90 | - | linker |
| Ser 91 | - | linker |
| Ala 92 | - | linker |
| Thr 93 | - | linker |
| Ser 94 | - | linker |
| Gly 95 | - | linker |
| Thr 96 | - | linker |
| Tyr 97 | - | linker |
| Lys 98 | - | linker |
| Tyr 99 | - | linker |
| Ile 100 | - | linker |
| Phe 101 | - | linker |
| Gly 102 | - | linker |
| Thr 103 | - | linker |
| Gly 104 | - | linker |
| Thr 105 | - | linker |
| Arg 106 | - | linker |
| Leu 107 | - | linker |
| Lys 108 | - | linker |
| Val 109 | - | linker |
| Leu 110 | - | linker |
| Ala 111 | - | linker |
| Asn 112 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ile 113 | Ile 118 | linker |
| Gln 114 | Gln 119 | linker |
| Asn 115 | Asn 120 | linker |
| Pro 116 | Pro 121 | linker |
| Asp 117 | Asp 122 | linker |
| Pro 118 | Pro 123 | linker |
| PDB | External Database | Details |
|---|---|---|
| Gln 96 | - | linker |
| Gly 97 | - | linker |
| Thr 98 | - | linker |
| Glu 99 | - | linker |
| Ala 100 | - | linker |
| Phe 101 | - | linker |
| Phe 102 | - | linker |
| Gly 103 | - | linker |
| Gln 104 | - | linker |
| Gly 105 | - | linker |
| Thr 106 | - | linker |
| Arg 107 | - | linker |
| Leu 108 | - | linker |
| Thr 109 | - | linker |
| Val 110 | - | linker |
| Val 111 | - | linker |
| Glu 112 | - | linker |
| Asp 113 | - | linker |
| Leu 114 | - | linker |
| Asn 115 | - | linker |
| Lys 116 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asp 200 | Asn 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94088.4 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 882.7 | |
| All* | Total formula weight | 94971.2 |
