3KXF

Crystal Structure of SB27 TCR in complex with the 'restriction triad' mutant HLA-B*3508-13mer

Summary for 3KXF

Entry DOI	10.2210/pdb3kxf/pdb
Related	2AK4 3KWW
Descriptor	HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, SB27 T cell receptor alpha chain, ... (7 entities in total)
Functional Keywords	mhc, hla, tcr, disulfide bond, host-virus interaction, immune response, membrane, mhc i, transmembrane, immunoglobulin domain, immune system
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P30685 Secreted: P61769 Host nucleus: P03206
Total number of polymer chains	20
Total formula weight	384872.25
Authors	Archbold, J.K.,Tynan, F.E.,Gras, S.,Rossjohn, J. (deposition date: 2009-12-03, release date: 2010-06-09, Last modification date: 2014-02-26)
Primary citation	Burrows, S.R.,Chen, Z.,Archbold, J.K.,Tynan, F.E.,Beddoe, T.,Kjer-Nielsen, L.,Miles, J.J.,Khanna, R.,Moss, D.J.,Liu, Y.C.,Gras, S.,Kostenko, L.,Brennan, R.M.,Clements, C.S.,Brooks, A.G.,Purcell, A.W.,McCluskey, J.,Rossjohn, J. Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability Proc.Natl.Acad.Sci.USA, 107:10608-10613, 2010 Cited by PubMed: 20483993 DOI: 10.1073/pnas.1004926107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation