3KXF
Crystal Structure of SB27 TCR in complex with the 'restriction triad' mutant HLA-B*3508-13mer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, I, P (A, C, K, I) | HLA class I histocompatibility antigen, B-35 alpha chain | polymer | 276 | 31840.2 | 4 | UniProt (P30685) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P01889) | Homo sapiens (human) | MHC class I antigen B*35 |
| 2 | B, F, J, Q (B, F, L, J) | Beta-2-microglobulin | polymer | 99 | 11748.2 | 4 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | Beta-2-microglobulin form pI 5.3 |
| 3 | D, G, K, R (D, G, N, M) | SB27 T cell receptor alpha chain | polymer | 204 | 23251.5 | 4 | Pfam (PF09291) UniProt (by SIFTS) (P01848) | Homo sapiens (human) | |
| 4 | E, H, L, S (E, H, P, O) | SB27 T cell receptor beta chain | polymer | 241 | 27190.2 | 4 | Pfam (PF07654) UniProt (by SIFTS) (A0A5B9) | Homo sapiens (human) | |
| 5 | M, N, O, T (Q, R, T, S) | peptide from Trans-activator protein BZLF1 | polymer | 13 | 1426.6 | 4 | UniProt (P03206) | EB1, Protein zebra | |
| 6 | AA, BA, CA, DA, EA... (C, D, E, F, G...) | IODIDE ION | non-polymer | 126.9 | 24 | Chemie (IOD) | |||
| 7 | AB, BB, CB, DB, EB... (N, P, I, J, M...) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A, C, K, I: 1 - 276 (UniProt: P30685)
| PDB | External Database | Details |
|---|---|---|
| Ala 65 | Gln 89 | engineered mutation |
| Ala 69 | Thr 93 | engineered mutation |
| Ala 155 | Gln 179 | engineered mutation |
| Arg 156 | Leu 180 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 381826.6 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 3045.7 | |
| All* | Total formula weight | 384872.3 |
