3HG1

Germline-governed recognition of a cancer epitope by an immunodominant human T cell receptor

Summary for 3HG1

DescriptorMHC class I antigen, Beta-2-microglobulin, CANCER/MART-1, ... (8 entities in total)
Functional Keywordst-cell receptor, cdr3, phage display, melan-1, mart-1, immune system, disulfide bond, transmembrane, disease mutation, glycation, glycoprotein, immune response, immunoglobulin domain, mhc i, pyrrolidone carboxylic acid, secreted
Biological sourceHomo sapiens (human)
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Cellular locationSecreted P61769
Total number of polymer chains5
Total molecular weight93827.93
Authors
Cole, D.K.,Yuan, F.,Rizkallah, P.J.,Miles, J.J.,Gostick, E.,Price, D.A.,Gao, G.F.,Jakobsen, B.K.,Sewell, A.K. (deposition date: 2009-05-13, release date: 2009-07-28, Last modification date: 2014-04-09)
Primary citation
Cole, D.K.,Yuan, F.,Rizkallah, P.J.,Miles, J.J.,Gostick, E.,Price, D.A.,Gao, G.F.,Jakobsen, B.K.,Sewell, A.K.
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
J.Biol.Chem., 284:27281-27289, 2009
PubMed: 19605354 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M109.022509
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.306728.5%4.0%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3hg1
no rotation
Molmil generated image of 3hg1
rotated about x axis by 90°
Molmil generated image of 3hg1
rotated about y axis by 90°