3HG1
Germline-governed recognition of a cancer epitope by an immunodominant human T cell receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MHC class I antigen | polymer | 276 | 31951.3 | 1 | UniProt (Q8WLS4) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (human) | MHC CLASS I ANTIGEN A*2 |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | Beta-2-microglobulin |
| 3 | C (C) | CANCER/MART-1 | polymer | 10 | 985.2 | 1 | UniProt (by SIFTS) (Q16655) | Homo sapiens | MELAN-A, MART-1 PROTEIN, AUTOIMMUNOGENIC CANCER/TESTIS ANTIGEN NY-ESO-1 |
| 4 | D (D) | T-CELL RECEPTOR, ALPHA CHAIN | polymer | 194 | 21371.4 | 1 | Pfam (PF09291) UniProt (by SIFTS) (P01848) | HOMO SAPIENS (human) | |
| 5 | E (E) | T-cell Receptor, Beta Chain | polymer | 244 | 27264.4 | 1 | Pfam (PF07654) UniProt (by SIFTS) (P01850) | HOMO SAPIENS (human) | |
| 6 | F, I (A, E) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | G, H (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 8 | J, K, L, M, N (A, B, C, D, E) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
B: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 93451.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 376.3 | |
| All* | Total formula weight | 93827.9 |
