5MEP

Human Leukocyte Antigen A02 presenting ILGKFLHWL

Summary for 5MEP

DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ILE-LEU-GLY-LYS-PHE-LEU-HIS-TRP-LEU, ... (6 entities in total)
Functional Keywordshla a02, hlaa, mhc, immuno, telomerase, immune system
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein P01892
Secreted . Note=(Microbial infection) In the presence of M P61769
Total number of polymer chains6
Total molecular weight90696.97
Authors
Rizkallah, P.J.,Cole, D.K.,Lloyd, A.,Crowther, M.,Sewell, A.K. (deposition date: 2016-11-16, release date: 2016-12-07, Last modification date: 2017-02-01)
Primary citation
Cole, D.K.,van den Berg, H.A.,Lloyd, A.,Crowther, M.D.,Beck, K.,Ekeruche-Makinde, J.,Miles, J.J.,Bulek, A.M.,Dolton, G.,Schauenburg, A.J.,Wall, A.,Fuller, A.,Clement, M.,Laugel, B.,Rizkallah, P.J.,Wooldridge, L.,Sewell, A.K.
Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
J. Biol. Chem., 292:802-813, 2017
PubMed: 27903649 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M116.741603
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.71 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.238509.9%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5mep
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Molmil generated image of 5mep
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Molmil generated image of 5mep
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More Biological unit images

Molmil generated image of 5mep
no rotation
Molmil generated image of 5mep
rotated about x axis by 90°
Molmil generated image of 5mep
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5mep.pdb2.gz [136.89 KB])
Coordinate files for Biological unit (5mep.pdb1.gz [137.05 KB])