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1O07
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN Q120L/Y150E MUTANT OF AMPC AND A BETA-LACTAM INHIBITOR (MXG)
Descriptor:Beta-lactamase, POTASSIUM ION, 2-(1-{2-[4-(2-ACETYLAMINO-PROPIONYLAMINO)-4-CARBOXY-BUTYRYLAMINO]-6-AMINO-HEXANOYLAMINO}-2-OXO-ETHYL)-5-METHYLENE-5,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID
Authors:Meroueh, S.O., Minasov, G., Lee, W., Shoichet, B.K., Mobashery, S.
Deposit date:2003-02-20
Release date:2003-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structural Aspects for Evolution of beta-Lactamases from Penicillin-Binding Proteins
J.Am.Chem.Soc., 125, 2003
1XKZ
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CRYSTAL STRUCTURE OF THE ACYLATED BETA-LACTAM SENSOR DOMAIN OF BLAR1 FROM S. AUREUS
Descriptor:Regulatory protein blaR1, ACYLATED CEFTAZIDIME, SULFATE ION, ...
Authors:Birck, C., Cha, J.Y., Cross, J., Schulze-Briese, C., Meroueh, S.O., Schlegel, H.B., Mobashery, S., Samama, J.-P.
Deposit date:2004-09-30
Release date:2004-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction
J.Am.Chem.Soc., 126, 2004
2F4S
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A-SITE RNA IN COMPLEX WITH NEAMINE
Descriptor:5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', (2R,3S,4R,5R,6R)-6-((1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYLOXY)-5-AMINO-2-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-3,4-DIOL
Authors:Murray, J.B., Meroueh, S.O., Russell, R.J., Lentzen, G., Haddad, J., Mobashery, S.
Deposit date:2005-11-24
Release date:2006-05-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site
Chem.Biol., 13, 2006
2F4T
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ASITE RNA + DESIGNER ANTIBIOTIC
Descriptor:5'-R(*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', (2R)-4-AMINO-N-{(1R,2S,3R,4R,5S)-5-AMINO-2-{2-[(2-AMINOETHYL)AMINO]ETHOXY}-4-[(2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-3-HYDROXYCYCLOHEXYL}-2-HYDROXYBUTANAMIDE
Authors:Murray, J.B., Meroueh, S.O., Russell, R.J., Lentzen, G., Haddad, J., Mobashery, S.
Deposit date:2005-11-24
Release date:2006-05-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site
Chem.Biol., 13, 2006
2F4U
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ASITE RNA + DESIGNER ANTIBIOTIC
Descriptor:5'-R(*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', (2R)-4-AMINO-N-((1R,2S,3R,4R,5S)-5-AMINO-4-[(2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-{2-[(3-AMINOPROPYL)AMINO]ETHOXY}-3-HYDROXYCYCLOHEXYL)-2-HYDROXYBUTANAMIDE
Authors:Murray, J.B., Meroueh, S.O., Russell, R.J., Lentzen, G., Haddad, J., Mobashery, S.
Deposit date:2005-11-24
Release date:2006-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site
Chem.Biol., 13, 2006
2F4V
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30S RIBOSOME + DESIGNER ANTIBIOTIC
Descriptor:16S ribosomal RNA, 5'-R(P*UP*UP*CP*U)-3', 30S ribosomal protein S2, ...
Authors:Murray, J.B., Meroueh, S.O., Russell, R.J., Lentzen, G., Haddad, J., Mobashery, S.
Deposit date:2005-11-24
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Interactions of designer antibiotics and the bacterial ribosome aminoacyl-tRNA site
Chem.Biol., 13, 2006
6E5G
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CRYSTAL STRUCTURE OF HUMAN TEAD2-YAP BINDING DOMAIN COVALENTLY BOUND TO AN ALLOSTERIC REGULATOR
Descriptor:Transcriptional enhancer factor TEF-4, 1-(2-{[3-(trifluoromethyl)phenyl]amino}phenyl)ethan-1-one
Authors:Bum-Erdene, K., Gonzalez-Gutierrez, G., Meroueh, S.O.
Deposit date:2018-07-20
Release date:2019-01-09
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction.
Cell Chem Biol, 26, 2019