8FJI
Crystal structure of RalA in a covalent complex with SOF-367
Summary for 8FJI
Entry DOI | 10.2210/pdb8fji/pdb |
Descriptor | Ras-related protein Ral-A, GUANOSINE-5'-DIPHOSPHATE, 8-[fluoro(dihydroxy)-lambda~4~-sulfanyl]-N-(2-methoxypyridin-3-yl)-2,3-dihydro-1,4-benzodioxine-5-sulfonamide, ... (5 entities in total) |
Functional Keywords | rala, gtpase, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 22271.67 |
Authors | Landgraf, A.D.,Yeh, I.-J.,Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Meroueh, S. (deposition date: 2022-12-19, release date: 2023-12-06) |
Primary citation | Landgraf, A.D.,Yeh, I.J.,Ghozayel, M.K.,Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Meroueh, S.O. Exploring Covalent Bond Formation at Tyr-82 for Inhibition of Ral GTPase Activation. Chemmedchem, 18:e202300272-e202300272, 2023 Cited by PubMed: 37269475DOI: 10.1002/cmdc.202300272 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.48 Å) |
Structure validation
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