8FJH

Crystal structure of RalA in a covalent complex with SOF-531

Summary for 8FJH

• Entry DOI: 10.2210/pdb8fjh/pdb
• Descriptor: Ras-related protein Ral-A, GUANOSINE-5'-DIPHOSPHATE, 8-[bis(oxidanyl)-$l^{3}-sulfanyl]-~{N}-(3-fluoranyl-5-methoxy-phenyl)-2,3-dihydro-1,4-benzodioxine-5-sulfonamide, ... (5 entities in total)
• Functional Keywords: rala, gtpase, inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 22288.68

Authors

Landgraf, A.D.,Yeh, I.-J.,Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Meroueh, S. (deposition date: 2022-12-19, release date: 2023-12-06)

• Primary citation: Landgraf, A.D.,Yeh, I.J.,Ghozayel, M.K.,Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Meroueh, S.O.; Exploring Covalent Bond Formation at Tyr-82 for Inhibition of Ral GTPase Activation.; Chemmedchem, 18:e202300272-e202300272, 2023; PubMed: 37269475; DOI: 10.1002/cmdc.202300272

Experimental method

X-RAY DIFFRACTION (1.54 Å)