Author results

1HP4
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CRYSTAL STRUCTURE OF STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, CHLORIDE ION, SULFATE ION, ...
Authors:Mark, B.L.
Deposit date:2000-12-12
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.
J.Biol.Chem., 276, 2001
1HP5
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STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE COMPLEXED WITH INTERMEDIATE ANALOUGE NAG-THIAZOLINE
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, CHLORIDE ION, SULFATE ION, ...
Authors:Mark, B.L.
Deposit date:2000-12-12
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.
J.Biol.Chem., 276, 2001
1JAK
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STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE IN COMPLEX WITH (2R,3R,4S,5R)-2-ACETAMIDO-3,4-DIHYDROXY-5-HYDROXYMETHYL-PIPERIDINIUM CHLORIDE (IFG)
Descriptor:Beta-N-acetylhexosaminidase, SULFATE ION, CHLORIDE ION, ...
Authors:Mark, B.L., Vocadlo, D.J., Zhao, D., Knapp, S., Withers, S.G., James, M.N.
Deposit date:2001-05-30
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor.
J.Biol.Chem., 276, 2001
1NOU
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NATIVE HUMAN LYSOSOMAL BETA-HEXOSAMINIDASE ISOFORM B
Descriptor:beta-hexosaminidase beta chain, N-ACETYL-D-GLUCOSAMINE, GLYCEROL, ...
Authors:Mark, B.L., Mahuran, D.J., Cherney, M.M., Zhao, D., Knapp, S., James, M.N.G.
Deposit date:2003-01-16
Release date:2003-04-08
Last modified:2012-11-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease
J.Mol.Biol., 327, 2003
1NOW
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HUMAN LYSOSOMAL BETA-HEXOSAMINIDASE ISOFORM B IN COMPLEX WITH (2R,3R,4S,5R)-2-ACETAMIDO-3,4-DIHYDROXY-5-HYDROXYMETHYL-PIPERIDINIUM CHLORIDE (GALNAC-ISOFAGOMINE)
Descriptor:beta-hexosaminidase beta chain, N-ACETYL-D-GLUCOSAMINE, (2R,3R,4S,5R)-2-ACETAMIDO-3,4-DIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, ...
Authors:Mark, B.L., Mahuran, D.J., Cherney, M.M., Zhao, D., Knapp, S., James, M.N.G.
Deposit date:2003-01-16
Release date:2003-04-29
Last modified:2012-11-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease
J.Mol.Biol., 327, 2003
1NP0
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HUMAN LYSOSOMAL BETA-HEXOSAMINIDASE ISOFORM B IN COMPLEX WITH INTERMEDIATE ANALOGUE NAG-THIAZOLINE
Descriptor:Beta-hexosaminidase subunit beta, Beta-hexosaminidase subunit beta chain B, Beta-hexosaminidase subunit beta chain A, ...
Authors:Mark, B.L., Mahuran, D.J., Cherney, M.M., Zhao, D., Knapp, S., James, M.N.G.
Deposit date:2003-01-16
Release date:2003-04-29
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease
J.Mol.Biol., 327, 2003
3KOS
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STRUCTURE OF THE AMPR EFFECTOR BINDING DOMAIN FROM CITROBACTER FREUNDII
Descriptor:HTH-type transcriptional activator ampR, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL
Authors:Mark, B.L., Balcewich, M.D.
Deposit date:2009-11-13
Release date:2010-05-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal Structure of the AmpR Effector Binding Domain Provides Insight into the Molecular Regulation of Inducible AmpC beta-Lactamase.
J.Mol.Biol., 400, 2010
3KOT
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STRUCTURE OF THE CITROBACTER FREUNDII EFFECTOR BINDING DOMAIN CONTAINING THREE AMINO ACID SUBSTITUTIONS: T103V, S221A AND Y264F
Descriptor:HTH-type transcriptional activator ampR, GLYCEROL
Authors:Mark, B.L., Balcewich, M.D.
Deposit date:2009-11-13
Release date:2010-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the AmpR Effector Binding Domain Provides Insight into the Molecular Regulation of Inducible AmpC beta-Lactamase.
J.Mol.Biol., 400, 2010
6MK6
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CARBAPENEMASE VCC-1 FROM VIBRIO CHOLERAE N14-02106
Descriptor:Beta-lactamase
Authors:Mark, B.L., Vadlamani, G.
Deposit date:2018-09-25
Release date:2019-01-30
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis for the potent inhibition of the emerging carbapenemase VCC-1 by avibactam.
Antimicrob. Agents Chemother., 2019
6MKQ
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CARBAPENEMASE VCC-1 BOUND TO AVIBACTAM
Descriptor:Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide
Authors:Mark, B.L., Vadlamani, G.
Deposit date:2018-09-26
Release date:2019-01-30
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis for the potent inhibition of the emerging carbapenemase VCC-1 by avibactam.
Antimicrob. Agents Chemother., 2019
1M01
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WILDTYPE STREPTOMYCES PLICATUS BETA-HEXOSAMINIDASE IN COMPLEX WITH PRODUCT (GLCNAC)
Descriptor:Beta-N-acetylhexosaminidase, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:J Williams, S., Mark, B.L., Vocadlo, D.J., James, M.N.G., Withers, S.G.
Deposit date:2002-06-11
Release date:2003-01-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state.
J.Biol.Chem., 277, 2002
1M03
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MUTANT STREPTOMYCES PLICATUS BETA-HEXOSAMINIDASE (D313A) IN COMPLEX WITH PRODUCT (GLCNAC)
Descriptor:Beta-N-acetylhexosaminidase, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Williams, S.J., Mark, B.L., Vocadlo, D.J., James, M.N.G., Withers, S.G.
Deposit date:2002-06-11
Release date:2002-12-11
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state.
J.Biol.Chem., 277, 2002
1M04
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MUTANT STREPTOMYCES PLICATUS BETA-HEXOSAMINIDASE (D313N) IN COMPLEX WITH PRODUCT (GLCNAC)
Descriptor:Beta-N-acetylhexosaminidase, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Williams, S.J., Mark, B.L., Vocadlo, D.J., James, M.N.G., Withers, S.G.
Deposit date:2002-06-11
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state.
J.Biol.Chem., 277, 2002
1MBM
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NSP4 PROTEINASE FROM EQUINE ARTERITIS VIRUS
Descriptor:chymotrypsin-like serine protease
Authors:Barrette-Ng, I.H., Ng, K.K.-S., Mark, B.L., van Aken, D., Cherney, M.M., Garen, C., Kolodenko, Y., Gorbalenya, A.E., Snijder, E.J., James, M.N.G.
Deposit date:2002-08-03
Release date:2002-10-23
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Arterivirus nsp4: the smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole
J.Biol.Chem., 277, 2002
2GJX
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CRYSTALLOGRAPHIC STRUCTURE OF HUMAN BETA-HEXOSAMINIDASE A
Descriptor:Beta-hexosaminidase alpha chain, Beta-hexosaminidase beta chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Lemieux, M.J., Mark, B.L., Cherney, M.M., Withers, S.G., Mahuran, D.J., James, M.N.G.
Deposit date:2006-03-31
Release date:2006-06-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic structure of human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of GM2 Ganglioside Hydrolysis
J.Mol.Biol., 359, 2006
2GK1
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X-RAY CRYSTAL STRUCTURE OF NGT-BOUND HEXA
Descriptor:Beta-hexosaminidase subunit alpha, Beta-hexosaminidase subunit beta, Beta-hexosaminidase subunit beta chain B, ...
Authors:Lemieux, M.J., Mark, B.L., Cherney, M.M., Withers, S.G., Mahuran, D.J., James, M.N.
Deposit date:2006-03-31
Release date:2006-05-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Crystallographic Structure of Human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of G(M2) Ganglioside Hydrolysis.
J.Mol.Biol., 359, 2006
2OXN
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VIBRIO CHOLERAE FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ) IN COMPLEX WITH PUGNAC
Descriptor:Beta-hexosaminidase, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE
Authors:Balcewich, M., Mark, B.L.
Deposit date:2007-02-20
Release date:2007-06-12
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance.
J.Biol.Chem., 282, 2007
3GS6
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VIBRIO CHOLEREA FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ)IN COMPLEX WITH N-BUTYRYL-PUGNAC
Descriptor:Beta-hexosaminidase, [[(3R,4R,5S,6R)-3-(BUTANOYLAMINO)-4,5-DIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YLIDENE]AMINO] N-PHENYLCARBAMATE, GLYCEROL
Authors:Balcewich, M.D., Mark, B.L.
Deposit date:2009-03-26
Release date:2009-06-30
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ.
Protein Sci., 18, 2009
3GSM
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VIBRIO CHOLERAE FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ) BOUND TO N-VALERYL-PUGNAC
Descriptor:Beta-hexosaminidase, [[(3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(pentanoylamino)oxan-2-ylidene]amino] N-phenylcarbamate, GLYCEROL
Authors:Balcewich, M.D., Mark, B.L.
Deposit date:2009-03-27
Release date:2009-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ.
Protein Sci., 18, 2009
3PSE
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STRUCTURE OF A VIRAL OTU DOMAIN PROTEASE BOUND TO INTERFERON-STIMULATED GENE 15 (ISG15)
Descriptor:RNA polymerase, Ubiquitin-like protein ISG15, 3-AMINOPROPANE, ...
Authors:Bacik, J.P., James, T.W., Frias-Staheli, N., Garcia-Sastre, A., Mark, B.L.
Deposit date:2010-12-01
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PT2
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STRUCTURE OF A VIRAL OTU DOMAIN PROTEASE BOUND TO UBIQUITIN
Descriptor:RNA polymerase, Ubiquitin B, SULFATE ION, ...
Authors:James, T.W., Bacik, J.P., Frias-Staheli, N., Garcia-Sastre, A., Mark, B.L.
Deposit date:2010-12-02
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease.
Proc.Natl.Acad.Sci.USA, 108, 2011
3QBW
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA 1,6-ANHYDRO-N-ACTETYLMURAMIC ACID KINASE (ANMK) BOUND TO ADENOSINE DIPHOSPHATE
Descriptor:Anhydro-N-acetylmuramic acid kinase, ADENOSINE-5'-DIPHOSPHATE, SULFATE ION
Authors:Bacik, J.P., Martin, D.R., Mark, B.L.
Deposit date:2011-01-14
Release date:2011-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Molecular Basis of 1,6-Anhydro Bond Cleavage and Phosphoryl Transfer by Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase.
J.Biol.Chem., 286, 2011
3QBX
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA 1,6-ANHYDRO-N-ACTETYLMURAMIC ACID KINASE (ANMK) BOUND TO 1,6-ANHYDRO-N-ACTETYLMURAMIC ACID
Descriptor:Anhydro-N-acetylmuramic acid kinase, 2-(2-ACETYLAMINO-4-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCT-3-YLOXY)-PROPIONIC ACID, SULFATE ION
Authors:Bacik, J.P., Martin, D.R., Mark, B.L.
Deposit date:2011-01-14
Release date:2011-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular Basis of 1,6-Anhydro Bond Cleavage and Phosphoryl Transfer by Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase.
J.Biol.Chem., 286, 2011
4GVF
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CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ) BOUND TO GLCNAC
Descriptor:Beta-hexosaminidase, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Bacik, J.P., Mark, B.L.
Deposit date:2012-08-30
Release date:2012-12-12
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion.
Chem.Biol., 19, 2012
4GVG
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CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ)
Descriptor:Beta-hexosaminidase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Bacik, J.P., Mark, B.L.
Deposit date:2012-08-30
Release date:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion.
Chem.Biol., 19, 2012
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