1NP0
Human lysosomal beta-hexosaminidase isoform B in complex with intermediate analogue NAG-thiazoline
Summary for 1NP0
Entry DOI | 10.2210/pdb1np0/pdb |
Related | 1NOU 1NOW |
Descriptor | Beta-hexosaminidase subunit beta, Beta-hexosaminidase subunit beta chain B, Beta-hexosaminidase subunit beta chain A, ... (8 entities in total) |
Functional Keywords | (beta/alpha)8-barrel, homodimer, family 20 glycosidase, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 113436.50 |
Authors | Mark, B.L.,Mahuran, D.J.,Cherney, M.M.,Zhao, D.,Knapp, S.,James, M.N.G. (deposition date: 2003-01-16, release date: 2003-04-29, Last modification date: 2023-08-16) |
Primary citation | Mark, B.L.,Mahuran, D.J.,Cherney, M.M.,Zhao, D.,Knapp, S.,James, M.N.G. Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease J.Mol.Biol., 327:1093-1109, 2003 Cited by PubMed: 12662933DOI: 10.1016/S0022-2836(03)00216-X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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