1NP0

Human lysosomal beta-hexosaminidase isoform B in complex with intermediate analogue NAG-thiazoline

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, B)	Beta-hexosaminidase subunit beta	polymer	58	6416.4	2	UniProt (P07686) Pfam (PF14845)	Homo sapiens (Human)	Beta-N-acetylhexosaminidase subunit beta,Hexosaminidase subunit B,Cervical cancer proto-oncogene 7 protein,HCC-7,N-acetyl-beta-glucosaminidase subunit beta
2	B, E (C, E)	Beta-hexosaminidase subunit beta chain B	polymer	190	21653.6	2	UniProt (P07686) Pfam (PF14845) Pfam (PF00728)	Homo sapiens (Human)	Beta-N-acetylhexosaminidase subunit beta,Hexosaminidase subunit B,Cervical cancer proto-oncogene 7 protein,HCC-7,N-acetyl-beta-glucosaminidase subunit beta
3	C, F (D, F)	Beta-hexosaminidase subunit beta chain A	polymer	241	27818.5	2	UniProt (P07686) Pfam (PF00728)	Homo sapiens (Human)	Beta-N-acetylhexosaminidase subunit beta,Hexosaminidase subunit B,Cervical cancer proto-oncogene 7 protein,HCC-7,N-acetyl-beta-glucosaminidase subunit beta
4	G, H (G, H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	I, M (A, B)	3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL	non-polymer		219.3	2	Chemie (NGT)
6	J, K, N (A, B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
7	L (B)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
8	O, P (A, B)	water	water		18.0	244	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	111776.8
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	6
	Total formula weight	810.9
All*	Total formula weight	113436.5

*Water molecules are not included.